A Comparative Study about the Neuroprotective Effects of DHA-Enriched Phosphatidylserine and EPA-Enriched Phosphatidylserine against Oxidative Damage in Primary Hippocampal Neurons.
Alzheimer’s disease
DHA/EPA
oxidative stress
phosphatidylserine
primary hippocampal neurons
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
19 Jul 2023
19 Jul 2023
Historique:
received:
03
06
2023
revised:
13
07
2023
accepted:
18
07
2023
medline:
31
7
2023
pubmed:
28
7
2023
entrez:
28
7
2023
Statut:
epublish
Résumé
Nerve damage caused by accumulated oxidative stress is one of the characteristics and main mechanisms of Alzheimer's disease (AD). Previous studies have shown that phosphatidylserine (PS) rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) plays a significant role in preventing and mitigating the progression of AD. However, whether DHA-PS and EPA-PS can directly protect primary hippocampal neurons against oxidative damage has not been studied. Here, the neuroprotective functions of DHA-PS and EPA-PS against H
Identifiants
pubmed: 37504941
pii: md21070410
doi: 10.3390/md21070410
pmc: PMC10381609
pii:
doi:
Substances chimiques
Eicosapentaenoic Acid
AAN7QOV9EA
Docosahexaenoic Acids
25167-62-8
Neuroprotective Agents
0
Phosphatidylserines
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 32072145
Organisme : Qingdao Marine Science and Technology Center
ID : 2022QNLM030002-4
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