Collagen VI sustains cell stemness and chemotherapy resistance in glioblastoma.
Cancer stem cells
Collagen VI
DNA repair
Extracellular matrix
Glioblastoma
Therapy resistance
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
28 Jul 2023
28 Jul 2023
Historique:
received:
04
06
2023
accepted:
18
07
2023
revised:
11
07
2023
medline:
31
7
2023
pubmed:
28
7
2023
entrez:
28
7
2023
Statut:
epublish
Résumé
Microenvironmental factors are known fundamental regulators of the phenotype and aggressiveness of glioblastoma (GBM), the most lethal brain tumor, characterized by fast progression and marked resistance to treatments. In this context, the extracellular matrix (ECM) is known to heavily influence the behavior of cancer cells from several origins, contributing to stem cell niches, influencing tumor invasiveness and response to chemotherapy, mediating survival signaling cascades, and modulating inflammatory cell recruitment. Here, we show that collagen VI (COL6), an ECM protein widely expressed in both normal and pathological tissues, has a distinctive distribution within the GBM mass, strongly correlated with the most aggressive and phenotypically immature cells. Our data demonstrate that COL6 sustains the stem-like properties of GBM cells and supports the maintenance of an aggressive transcriptional program promoting cancer cell proliferation and survival. In particular, we identified a specific subset of COL6-transcriptionally co-regulated genes, required for the response of cells to replicative stress and DNA damage, supporting the concept that COL6 is an essential stimulus for the activation of GBM cell response and resistance to chemotherapy, through the ATM/ATR axis. Altogether, these findings indicate that COL6 plays a pivotal role in GBM tumor biology, exerting a pleiotropic action across different GBM hallmarks, including phenotypic identity and gene transcription, as well as response to treatments, thus providing valuable information for the understanding of the complex microenvironmental cues underlying GBM malignancy.
Identifiants
pubmed: 37505240
doi: 10.1007/s00018-023-04887-5
pii: 10.1007/s00018-023-04887-5
pmc: PMC10382393
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
233Subventions
Organisme : Istituto di Ricerca Pediatrica - Città della Speranza
ID : IRP18/06
Organisme : Fondazione Cassa di Risparmio di Padova e Rovigo
ID : 17/07_1 FCR
Organisme : Fondazione Cassa di Risparmio di Padova e Rovigo
ID : 20/16 FCR
Organisme : Fondazione Cassa di Risparmio di Padova e Rovigo
ID : 15-2016
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : 2015FBNB5Y
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : 201742SBXA
Organisme : Università degli Studi di Padova
ID : STARS Grants programme
Organisme : Università degli Studi di Padova
ID : PRID-DMM
Organisme : Fondazione Umberto Veronesi
ID : #2601
Organisme : Fondazione Umberto Veronesi
ID : #3628
Organisme : Fondazione Umberto Veronesi
ID : #4420
Organisme : Fondazione Umberto Veronesi
ID : #4820
Informations de copyright
© 2023. The Author(s).
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