Pre-dialysis care trajectory and post-dialysis survival and transplantation access in patients with end-stage kidney disease.
Care trajectory
Dialysis
End-stage renal disease
Kidney transplantation
Survival
Journal
Journal of nephrology
ISSN: 1724-6059
Titre abrégé: J Nephrol
Pays: Italy
ID NLM: 9012268
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
12
12
2022
accepted:
18
06
2023
medline:
2
10
2023
pubmed:
28
7
2023
entrez:
28
7
2023
Statut:
ppublish
Résumé
The pre-dialysis care trajectory impact on post-dialysis outcomes is poorly known. This study assessed survival, access to kidney transplant waiting list and to transplantation after dialysis initiation by taking into account the patients' pre-dialysis care consumption (inpatient and outpatient) and the conditions of dialysis start: initiation context (emergency or planned) and vascular access type (catheter or fistula). Adults who started dialysis in France in 2015 were included. Clinical data came from the French REIN registry and data on the care trajectory from the French National Health Data system (SNDS). The Cox model was used to assess survival and access to kidney transplantation. We included 8856 patients with a mean age of 68 years. Survival was shorter in patients with emergency or planned dialysis initiation with a catheter compared to patients with planned dialysis with a fistula. The risk of death was lower in patients who were seen by a nephrologist more than once in the 6 months before dialysis than in those who were seen only once. The rate of kidney transplant at 1 year post-dialysis was lower for patients with emergency or planned dialysis initiation with a catheter (respectively, HR = 0.5 [0.4; 0.8] and HR = 0.7 [0.5; 0.9]) compared to patients with planned dialysis start with a fistula. Patients who were seen by a nephrologist more than three times between 0 and 6 months before dialysis start were more likely to access the waiting list 1 and 3 years after dialysis start (respectively, HR = 1.3 [1.1; 1.5] and HR = 1.2 [1.1; 1.4]). Nephrological follow-up in the year before dialysis initiation is associated with better survival and higher probability of access to kidney transplantation. These results emphasize the importance of early patient referral to nephrologists by general practitioners.
Sections du résumé
BACKGROUND
The pre-dialysis care trajectory impact on post-dialysis outcomes is poorly known. This study assessed survival, access to kidney transplant waiting list and to transplantation after dialysis initiation by taking into account the patients' pre-dialysis care consumption (inpatient and outpatient) and the conditions of dialysis start: initiation context (emergency or planned) and vascular access type (catheter or fistula).
METHODS
Adults who started dialysis in France in 2015 were included. Clinical data came from the French REIN registry and data on the care trajectory from the French National Health Data system (SNDS). The Cox model was used to assess survival and access to kidney transplantation.
RESULTS
We included 8856 patients with a mean age of 68 years. Survival was shorter in patients with emergency or planned dialysis initiation with a catheter compared to patients with planned dialysis with a fistula. The risk of death was lower in patients who were seen by a nephrologist more than once in the 6 months before dialysis than in those who were seen only once. The rate of kidney transplant at 1 year post-dialysis was lower for patients with emergency or planned dialysis initiation with a catheter (respectively, HR = 0.5 [0.4; 0.8] and HR = 0.7 [0.5; 0.9]) compared to patients with planned dialysis start with a fistula. Patients who were seen by a nephrologist more than three times between 0 and 6 months before dialysis start were more likely to access the waiting list 1 and 3 years after dialysis start (respectively, HR = 1.3 [1.1; 1.5] and HR = 1.2 [1.1; 1.4]).
CONCLUSIONS
Nephrological follow-up in the year before dialysis initiation is associated with better survival and higher probability of access to kidney transplantation. These results emphasize the importance of early patient referral to nephrologists by general practitioners.
Identifiants
pubmed: 37505404
doi: 10.1007/s40620-023-01711-y
pii: 10.1007/s40620-023-01711-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2057-2070Informations de copyright
© 2023. The Author(s) under exclusive licence to Italian Society of Nephrology.
Références
Guide parcours de soins maladie rénale chronique de l’adulte [Internet]. Haute Autorité de Santé. Available from: https://www.has-sante.fr/jcms/c_1241102/fr/guide-parcours-de-soins-maladie-renale-chronique-de-l-adulte . Accessed 27 Aug 2021
Lameire NH, Levin A, Kellum JA, Cheung M, Jadoul M, Winkelmayer WC et al (2021) Harmonizing acute and chronic kidney disease definition and classification: report of a kidney disease: improving global outcomes (KDIGO) consensus conference. Kidney Int 100(3):516–526
pubmed: 34252450
Johansen KL, Chertow GM, Foley RN, Gilbertson DT, Herzog CA, Ishani A et al (2021) US renal data system 2020 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis 77(4 Suppl 1):A7
pubmed: 33752804
pmcid: 8148988
Pippias M, Jager KJ, Kramer A, Leivestad T, Sánchez MB, Caskey FJ et al (2016) The changing trends and outcomes in renal replacement therapy: data from the ERA-EDTA registry. Nephrol Dial Transplant 31(5):831–841
pubmed: 26361801
Rapport_rein_2019_2021–10–14.pdf [Internet]. Available from: https://www.agence-biomedecine.fr/IMG/pdf/rapport_rein_2019_2021-10-14.pdf . Accessed 4 May 2022
Tonelli M, Wiebe N, Manns BJ, Klarenbach SW, James MT, Ravani P et al (2018) Comparison of the complexity of patients seen by different medical subspecialists in a Universal Health Care System. JAMA Netw Open 1(7):e184852
pubmed: 30646392
pmcid: 6324421
Guide_remplissage_diadem_2017_version_finale.pdf [Internet]. Available from: https://www.agence-biomedecine.fr/IMG/pdf/guide_remplissage_diadem_2017_version_finale.pdf . Accessed 14 Sept 2021
Weckmann GFC, Stracke S, Haase A, Spallek J, Ludwig F, Angelow A et al (2018) Diagnosis and management of non-dialysis chronic kidney disease in ambulatory care: a systematic review of clinical practice guidelines. BMC Nephrol 11(19):258
Mendelssohn DC, Malmberg C, Hamandi B (2009) An integrated review of ‘unplanned’ dialysis initiation: reframing the terminology to ‘suboptimal’ initiation. BMC Nephrol 12(10):22
Hassan R, Akbari A, Brown PA, Hiremath S, Brimble KS, Molnar AO (2019) Risk factors for unplanned dialysis initiation: a systematic review of the literature. Can J Kidney Health Dis 6:2054358119831684
pubmed: 30899532
pmcid: 6419254
Park JI, Kim M, Kim H, An JN, Lee J, Yang SH et al (2015) Not early referral but planned dialysis improves quality of life and depression in newly diagnosed end stage renal disease patients: a prospective cohort study in Korea. PLoS ONE 10(2):e0117582
pubmed: 25706954
pmcid: 4338188
Panocchia N, Tazza L, Di Stasio E, Liberatori M, Vulpio C, Giungi S et al (2016) Mortality in hospitalized chronic kidney disease patients starting unplanned urgent haemodialysis. Nephrology (Carlton) 21(1):62–67
pubmed: 26173588
Chen YM, Wang YC, Hwang SJ, Lin SH, Wu KD (2016) Patterns of dialysis initiation affect outcomes of incident hemodialysis patients. Nephron 132(1):33–42
pubmed: 26588170
Michel A, Pladys A, Bayat S, Couchoud C, Hannedouche T, Vigneau C (2018) Deleterious effects of dialysis emergency start, insights from the French REIN registry. BMC Nephrol 19(1):233
pubmed: 30223784
Brown PA, Akbari A, Molnar AO, Taran S, Bissonnette J, Sood M et al (2015) Factors associated with unplanned dialysis starts in patients followed by nephrologists: a retropective cohort Study. PLoS ONE 10(6):e0130080
pubmed: 26047510
pmcid: 4457723
Descamps C, Labeeuw M, Trolliet P, Cahen R, Ecochard R, Pouteil-Noble C et al (2011) Confounding factors for early death in incident end-stage renal disease patients: role of emergency dialysis start. Hemodial Int 15(1):23–29
pubmed: 21223483
Xue H, Ix JH, Wang W, Sm B, Lazarus M, Hakim R et al (2013) Hemodialysis access usage patterns in the incident dialysis year and associated catheter-related complications. Am J Kidney Dis 61(1):123
pubmed: 23159234
Ravani P, Palmer SC, Oliver MJ, Quinn RR, MacRae JM, Tai DJ et al (2013) Associations between hemodialysis access type and clinical outcomes: a systematic review. J Am Soc Nephrol 24(3):465–473
pubmed: 23431075
pmcid: 3582202
Raithatha A, McKane W, Kendray D, Evans C (2010) Catheter access for hemodialysis defines higher mortality in late-presenting dialysis patients. Ren Fail 32(10):1183–1188
pubmed: 20954979
de Jager DJ, Voormolen N, Krediet RT, Dekker FW, Boeschoten EW, Grootendorst DC et al (2011) Association between time of referral and survival in the first year of dialysis in diabetics and the elderly. Nephrol Dial Transplant 26(2):652–658
pubmed: 20639517
Winkelmayer WC, Owen WF, Levin R, Avorn J (2003) A propensity analysis of late versus early nephrologist referral and mortality on dialysis. J Am Soc Nephrol 14(2):486–492
pubmed: 12538751
Kazmi WH, Obrador GT, Khan SS, Pereira BJG, Kausz AT (2004) Late nephrology referral and mortality among patients with end-stage renal disease: a propensity score analysis. Nephrol Dial Transplant 19(7):1808–1814
pubmed: 15199194
Stack AG (2003) Impact of timing of nephrology referral and pre-ESRD care on mortality risk among new ESRD patients in the United States. Am J Kidney Dis 41(2):310–318
pubmed: 12552491
Iwata Y, Okushima H, Takatsuka T, Yoshimura D, Kawamura T, Iio R et al (2020) Duration of predialysis nephrological care and mortality after dialysis initiation. Clin Exp Nephrol 24(8):705–714
pubmed: 32281008
Singhal R, Hux JE, Alibhai SMH, Oliver MJ (2014) Inadequate predialysis care and mortality after initiation of renal replacement therapy. Kidney Int 86(2):399–406
pubmed: 24552848
Smart NA, Dieberg G, Ladhani M, Titus T (2014) Early referral to specialist nephrology services for preventing the progression to end-stage kidney disease. Cochrane Database Syst Rev 18(6):CD007333
Kim DH, Kim M, Kim H, Kim YL, Kang SW, Yang CW et al (2013) Early referral to a nephrologist improved patient survival: prospective cohort study for end-stage renal disease in Korea. PLoS ONE 8(1):e55323
pubmed: 23372849
pmcid: 3555934
Lu JL, Molnar MZ, Sumida K, Diskin CD, Streja E, Siddiqui OA et al (2018) Association of the frequency of pre-end-stage renal disease medical care with post-end-stage renal disease mortality and hospitalization. Nephrol Dial Transplant 33(5):789–795
pubmed: 29106625
Pisoni RL, Arrington CJ, Albert JM, Ethier J, Kimata N, Krishnan M et al (2009) Facility hemodialysis vascular access use and mortality in countries participating in DOPPS: an instrumental variable analysis. Am J Kidney Dis 53(3):475–491
pubmed: 19150158
Couchoud C, Stengel B, Landais P, Aldigier JC, de Cornelissen F, Dabot C et al (2006) The renal epidemiology and information network (REIN): a new registry for end-stage renal disease in France. Nephrol Dial Transplant 21(2):411–418
pubmed: 16234286
Raffray M, Bayat S, Lassalle M, Couchoud C (2020) Linking disease registries and nationwide healthcare administrative databases: the French renal epidemiology and information network (REIN) insight. BMC Nephrol 21(1):25
pubmed: 31992233
pmcid: 6988267
Raffray M, Vigneau C, Couchoud C, Bayat S (2021) Predialysis care trajectories of patients with ESKD starting dialysis in emergency in France. Kidney Int Rep 6(1):156–167
pubmed: 33426395
Sterne JAC, White IR, Carlin JB, Spratt M, Royston P, Kenward MG et al (2009) Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 338(jun29 1):b2393
pubmed: 19564179
pmcid: 2714692
Andersen PK, Geskus RB, de Witte T, Putter H (2012) Competing risks in epidemiology: possibilities and pitfalls. Int J Epidemiol 41(3):861–870
pubmed: 22253319
pmcid: 3396320
Noordzij M, Leffondré K, van Stralen KJ, Zoccali C, Dekker FW, Jager KJ (2013) When do we need competing risks methods for survival analysis in nephrology? Nephrol Dial Transplant 28(11):2670–2677
pubmed: 23975843
Wolbers M, Koller MT, Stel VS, Schaer B, Jager KJ, Leffondré K et al (2014) Competing risks analyses: objectives and approaches. Eur Heart J 35(42):2936–2941
pubmed: 24711436
pmcid: 4223609
Marrón B, Ortiz A, de Sequera P, Martín-Reyes G, de Arriba G, Lamas JM et al (2006) Impact of end-stage renal disease care in planned dialysis start and type of renal replacement therapy–a Spanish multicentre experience. Nephrol Dial Transplant 21(Suppl 2):ii51-55
pubmed: 16825262
Cho EJ, Park HC, Yoon HB, Ju KD, Kim H, Oh YK et al (2012) Effect of multidisciplinary pre-dialysis education in advanced chronic kidney disease: propensity score matched cohort analysis. Nephrology (Carlton) 17(5):472–479
pubmed: 22435951
Chiu K, Alam A, Iqbal S (2012) Predictors of suboptimal and crash initiation of dialysis at two tertiary care centers. Hemodial Int 16(Suppl 1):S39-46
pubmed: 23036035
Gomis Couto A, Teruel Briones JL, Fernández Lucas M, Rivera Gorrin M, Rodríguez Mendiola N, Jiménez Álvaro S et al (2011) Causes of unplanned hemodialysis initiation. Nefrologia 31(6):733–737
pubmed: 22130290
Kanno A, Nakayama M, Sanada S, Sato M, Sato T, Taguma Y (2019) Suboptimal initiation predicts short-term prognosis and vulnerability among very elderly patients who start haemodialysis. Nephrology (Carlton) 24(1):94–101
pubmed: 29131496
Metcalfe W, Khan IH, Prescott GJ, Simpson K, MacLeod AM (2000) Can we improve early mortality in patients receiving renal replacement therapy? Kidney Int 57(6):2539–2545
pubmed: 10844623
Frimat L, Loos-Ayav C, Panescu V, Cordebar N, Briançon S, Kessler M (2004) Early referral to a nephrologist is associated with better outcomes in type 2 diabetes patients with end-stage renal disease. Diabetes Metab 30(1):67–74
pubmed: 15029100
Yoon HE, Chung S, Chung HW, Shin MJ, Lee SJ, Kim YS et al (2009) Status of initiating pattern of hemodialysis: a multi-center study. J Korean Med Sci 24(Suppl):S102-108
pubmed: 19194537
pmcid: 2633201
Teo BW, Ma V, Xu H, Li J, Lee EJ, Nephrology Clinical Research Group (2010) Profile of hospitalisation and death in the first year after diagnosis of end-stage renal disease in a multi-ethnic Asian population. Ann Acad Med Singapore 39(2):79–87
pubmed: 20237727
Béchade C, Dejardin O, Bara S, Bouvier V, Guizard AV, De Mil R et al (2018) Incidence and characteristics of chronic renal replacement therapy in patients with cancer: data from kidney and cancer registries in Basse-Normandie. J Nephrol 31(1):111–118
pubmed: 27815918
Buck J, Baker R, Cannaby AM, Nicholson S, Peters J, Warwick G (2007) Why do patients known to renal services still undergo urgent dialysis initiation? A cross-sectional survey. Nephrol Dial Transplant 22(11):3240–3245
pubmed: 17616535
Crews DC, Jaar BG, Plantinga LC, Kassem HS, Fink NE, Powe NR (2010) Inpatient hemodialysis initiation: reasons, risk factors and outcomes. Nephron Clin Pract 114(1):c19-28
pubmed: 19816040
Hughes SA, Mendelssohn JG, Tobe SW, McFarlane PA, Mendelssohn DC (2013) Factors associated with suboptimal initiation of dialysis despite early nephrologist referral. Nephrol Dial Transplant 28(2):392–397
pubmed: 23222418
Piwko C, Vicente C, Marra L, Jivraj F, Appel E, Wolpin J et al (2012) The STARRT trial: a cost comparison of optimal vs sub-optimal initiation of dialysis in Canada. J Med Econ 15(1):96–104
pubmed: 21988636
Nadeau-Fredette AC, Tennankore KK, Kim SJ, Chan CT (2013) Suboptimal initiation of home hemodialysis: determinants and clinical outcomes. Nephron Clin Pract 124(1–2):132–140
pubmed: 24281264
Chantrel F (2010) Démarrage d’un traitement par dialyse chronique en urgence. Quels patients? Quelles conséquences? BEH thématique (9–10):81–86
Alizada U, Sauleau EA, Krummel T, Moranne O, Kazes I, Couchoud C et al (2021) Effect of emergency start and central venous catheter on outcomes in incident hemodialysis patients: a prospective observational cohort. J Nephrol. https://doi.org/10.1007/s40620-021-01188-7
doi: 10.1007/s40620-021-01188-7
pubmed: 34817835
Filc D, Davidovich N, Novack L, Balicer RD (2014) Is socioeconomic status associated with utilization of health care services in a single-payer universal health care system? Int J Equity Health. https://doi.org/10.1186/s12939-014-0115-1
doi: 10.1186/s12939-014-0115-1
pubmed: 25431139
pmcid: 4260253
Kasiske BL, London W, Ellison MD (1998) Race and socioeconomic factors influencing early placement on the kidney transplant waiting list. J Am Soc Nephrol 9(11):2142
pubmed: 9808103
Zhang Y, Gerdtham UG, Rydell H, Jarl J (2018) Socioeconomic inequalities in the kidney transplantation process: a registry-based study in Sweden. Transplant Direct 4(2):e346
pubmed: 29796417
pmcid: 5959348
Pruthi R, Robb ML, Oniscu GC, Tomson C, Bradley A, Forsythe JL et al (2020) Inequity in access to transplantation in the United Kingdom. Clin J Am Soc Nephrol 15(6):830
pubmed: 32467306
pmcid: 7274279
Calvar E, Launay L, Bayat-Makoei S, Bauwens M, Lassalle M, Couchoud C et al (2023) Social deprivation reduced registration for kidney transplantation through markers of nephrological care: a mediation analysis. J Clin Epidemiol 10(157):92–101
Boonstra MD, Reijneveld SA, Foitzik EM, Westerhuis R, Navis G, de Winter AF (2020) How to tackle health literacy problems in chronic kidney disease patients? A systematic review to identify promising intervention targets and strategies. Nephrol Dial Transplant 36(7):1207–1221
pubmed: 33351936
pmcid: 8237988
Taylor DM, Fraser SDS, Bradley JA, Bradley C, Draper H, Metcalfe W et al (2017) A Systematic review of the prevalence and associations of limited health literacy in CKD. Clin J Am Soc Nephrol 12(7):1070–1084
pubmed: 28487346
pmcid: 5498363