Investigating three ways of measuring the intrinsic capacity domain of vitality: nutritional status, handgrip strength and ageing biomarkers.
biological ageing
disability
healthy ageing
inflammation
older people
structural equation modelling
Journal
Age and ageing
ISSN: 1468-2834
Titre abrégé: Age Ageing
Pays: England
ID NLM: 0375655
Informations de publication
Date de publication:
01 07 2023
01 07 2023
Historique:
received:
09
09
2022
revised:
07
04
2023
medline:
31
7
2023
pubmed:
28
7
2023
entrez:
28
7
2023
Statut:
ppublish
Résumé
Vitality is conceptually considered as the underlying capacity influencing other intrinsic capacity (IC) domains and being related to nutrition, physiological reserve and biological ageing. However, there is no consensus on its operationalisation. To investigate the structure and magnitude of the association of vitality with other IC domains and functional difficulties using three operational definitions of vitality. We included 1,389 older adults from the Multidomain Alzheimer Preventive Trial with data on Mini Nutritional Assessment (MNA), handgrip strength and plasma biomarkers (comprising inflammatory and mitochondrial markers). Using path analysis, we examined the effects of vitality on difficulties in basic and instrumental activities of daily living (ADL and IADL) exerted directly and indirectly through the mediation of other IC domains: cognition, locomotion, psychological, vision and hearing. We further explored the longitudinal association of vitality with IC domains, ADL and IADL over 4 years using linear mixed-effect regression. We observed significant indirect effects of vitality on IADL, mainly through cognitive, locomotor and psychological domains, regardless of the vitality measurement. Participants with higher vitality had fewer IADL difficulties at follow-up (MNA score: β [95% CI] = -0.020 [-0.037, -0.003]; handgrip strength: -0.011 [-0.023, 0.000]; plasma biomarker-based index: -0.015 [-0.028, -0.002]). Vitality assessed with the plasma biomarker-based index predicted improved locomotion over time. Vitality was associated with disability primarily through the mediation of other IC domains. The three indicators examined are acceptable measurements of vitality; biomarkers might be more suitable for the early detection of locomotion decline.
Sections du résumé
BACKGROUND
Vitality is conceptually considered as the underlying capacity influencing other intrinsic capacity (IC) domains and being related to nutrition, physiological reserve and biological ageing. However, there is no consensus on its operationalisation.
OBJECTIVE
To investigate the structure and magnitude of the association of vitality with other IC domains and functional difficulties using three operational definitions of vitality.
METHODS
We included 1,389 older adults from the Multidomain Alzheimer Preventive Trial with data on Mini Nutritional Assessment (MNA), handgrip strength and plasma biomarkers (comprising inflammatory and mitochondrial markers). Using path analysis, we examined the effects of vitality on difficulties in basic and instrumental activities of daily living (ADL and IADL) exerted directly and indirectly through the mediation of other IC domains: cognition, locomotion, psychological, vision and hearing. We further explored the longitudinal association of vitality with IC domains, ADL and IADL over 4 years using linear mixed-effect regression.
RESULTS
We observed significant indirect effects of vitality on IADL, mainly through cognitive, locomotor and psychological domains, regardless of the vitality measurement. Participants with higher vitality had fewer IADL difficulties at follow-up (MNA score: β [95% CI] = -0.020 [-0.037, -0.003]; handgrip strength: -0.011 [-0.023, 0.000]; plasma biomarker-based index: -0.015 [-0.028, -0.002]). Vitality assessed with the plasma biomarker-based index predicted improved locomotion over time.
CONCLUSION
Vitality was associated with disability primarily through the mediation of other IC domains. The three indicators examined are acceptable measurements of vitality; biomarkers might be more suitable for the early detection of locomotion decline.
Identifiants
pubmed: 37505993
pii: 7232307
doi: 10.1093/ageing/afad133
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Bruno Vellas
(B)
Sophie Guyonnet
(S)
Isabelle Carrié
(I)
Lauréane Brigitte
(L)
Catherine Faisant
(C)
Françoise Lala
(F)
Julien Delrieu
(J)
Hélène Villars
(H)
Emeline Combrouze
(E)
Carole Badufle
(C)
Audrey Zueras
(A)
Sandrine Andrieu
(S)
Christelle Cantet
(C)
Christophe Morin
(C)
Gabor Abellan Van Kan
(GA)
Charlotte Dupuy
(C)
Yves Rolland
(Y)
Céline Caillaud
(C)
Pierre-Jean Ousset
(PJ)
Françoise Lala
(F)
Jean-François Dartigues
(JF)
Isabelle Marcet
(I)
Fleur Delva
(F)
Alexandra Foubert
(A)
Sandrine Cerda
(S)
Olivier Rouaud
(O)
Patrick Manckoundia
(P)
Valérie Quipourt
(V)
Sophie Marilier
(S)
Evelyne Franon
(E)
Lawrence Bories
(L)
Marie-Laure Pader
(ML)
Marie-France Basset
(MF)
Bruno Lapoujade
(B)
Valérie Faure
(V)
Michael Li Yung Tong
(M)
Christine Malick-Loiseau
(C)
Evelyne Cazaban-Campistron
(E)
Françoise Desclaux
(F)
Colette Blatge
(C)
Thierry Dantoine
(T)
Cécile Laubarie-Mouret
(C)
Isabelle Saulnier
(I)
Jean-Pierre Clément
(JP)
Marie-Agnès Picat
(MA)
Laurence Bernard-Bourzeix
(L)
Stéphanie Willebois
(S)
Iléana Désormais
(I)
Noëlle Cardinaud
(N)
Marc Bonnefoy
(M)
Pierre Livet
(P)
Pascale Rebaudet
(P)
Claire Gédéon
(C)
Catherine Burdet
(C)
Alain Pesce
(A)
Stéphanie Roth
(S)
Sylvie Chaillou
(S)
Kristel Sudres
(K)
Nicolas Lebrun
(N)
Jacques Touchon
(J)
Karim Bennys
(K)
Audrey Gabelle
(A)
Aurélia Romano
(A)
Lynda Touati
(L)
Cécilia Marelli
(C)
Franck Le Duff
(F)
Claire Gervais
(C)
Sébastien Gonfrier
(S)
Yannick Gasnier
(Y)
Serge Bordes
(S)
Danièle Begorre
(D)
Christian Carpuat
(C)
Khaled Khales
(K)
Jean-François Lefebvre
(JF)
Samira Misbah El Idrissi
(SM)
Pierre Skolil
(P)
Jean-Pierre Salles
(JP)
Carole Dufouil
(C)
Stéphane Lehéricy
(S)
Marie Chupin
(M)
Jean-François Mangin
(JF)
Ali Bouhayia
(A)
Michèle Allard
(M)
Frédéric Ricolfi
(F)
Dominique Dubois
(D)
Marie Paule Bonceour Martel
(MP)
François Cotton
(F)
Alain Bonafé
(A)
Stéphane Chanalet
(S)
Françoise Hugon
(F)
Fabrice Bonneville
(F)
Christophe Cognard
(C)
François Chollet
(F)
Pierre Payoux
(P)
Thierry Voisin
(T)
Julien Delrieu
(J)
Sophie Peiffer
(S)
Anne Hitzel
(A)
Michèle Allard
(M)
Michel Zanca
(M)
Jacques Monteil
(J)
Jacques Darcourt
(J)
Bertrand Perret
(B)
Claire Vinel
(C)
Sylvie Caspar-Bauguil
(S)
Pascale Olivier-Abbal
(P)
Sandrine Andrieu
(S)
Christelle Cantet
(C)
Nicola Coley
(N)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.