Inflammasomes as regulators of non-infectious disease.
Cancer
Caspase
Development
Inflammasome
Inflammation
Innate immunity
Interleukin-1
Malignancy
NLRs
Pyroptosis
Reproduction
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
17
05
2023
revised:
13
07
2023
accepted:
20
07
2023
pmc-release:
01
09
2024
medline:
21
8
2023
pubmed:
29
7
2023
entrez:
28
7
2023
Statut:
ppublish
Résumé
Inflammasomes are cytoplasmic organelles that stimulate inflammation upon cellular detection of infectious or non-infectious stress. While much foundational work has focused on the infection-associated aspects of inflammasome activities, recent studies have highlighted the role of inflammasomes in non-infectious cellular and organismal functions. Herein, we discuss the evolution of inflammasome components and highlight characteristics that permit inflammasome regulation of physiologic processes. We focus on emerging data that highlight the importance of inflammasome proteins in the regulation of reproduction, development, and malignancy. A framework is proposed to contextualize these findings.
Identifiants
pubmed: 37506489
pii: S1044-5323(23)00106-9
doi: 10.1016/j.smim.2023.101815
pmc: PMC10527946
mid: NIHMS1921795
pii:
doi:
Substances chimiques
Inflammasomes
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101815Subventions
Organisme : NIAID NIH HHS
ID : R01 AI067993
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI116550
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034854
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL116275
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116550
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI167993
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declarations of Competing Interest J.C.K consults and holds equity in Corner Therapeutics, Larkspur Biosciences and Neumora Therapeutics. None of these relationships impacted this manuscript.
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