A contemporary review of clade-specific virological differences in monkeypox viruses.
Clades
Monkeypox virus
Mpox
Pathogenesis
Virology
Virulence
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN: 1469-0691
Titre abrégé: Clin Microbiol Infect
Pays: England
ID NLM: 9516420
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
10
03
2023
revised:
08
07
2023
accepted:
14
07
2023
medline:
29
11
2023
pubmed:
29
7
2023
entrez:
28
7
2023
Statut:
ppublish
Résumé
Monkeypox virus (MPXV) is an emerging zoonotic virus that has had on-going public health impacts in endemic regions of Central and West Africa for over a half-century. Historically, the MPXV clade endemic in regions of Central Africa is associated with higher morbidity and mortality as compared with the clade endemic in West Africa. Here, we review the virological characteristics of MPXV and discuss potential relationships between virulence factors and clade- (and subclade-) specific differences in virulence and transmission patterns. Targeted search was conducted in PubMed using ((monkeypox virus) OR (Orthopoxvirus)) AND (zoonosis)) OR ((monkeypox) OR (human mpox). Forty-seven references were considered that included three publicly available data reports and/or press releases, one book chapter, and 44 published manuscripts. Although zoonosis has been historically linked to emergence events in humans, epidemiological analyses of more recent outbreaks have identified increasing frequencies of human-to-human transmission. Furthermore, viral transmission during the 2022 global human mpox outbreak, caused by a recently identified MPXV subclade, has relied exclusively on human-to-human contact with no known zoonotic link.
Sections du résumé
BACKGROUND
BACKGROUND
Monkeypox virus (MPXV) is an emerging zoonotic virus that has had on-going public health impacts in endemic regions of Central and West Africa for over a half-century. Historically, the MPXV clade endemic in regions of Central Africa is associated with higher morbidity and mortality as compared with the clade endemic in West Africa.
OBJECTIVES
OBJECTIVE
Here, we review the virological characteristics of MPXV and discuss potential relationships between virulence factors and clade- (and subclade-) specific differences in virulence and transmission patterns.
SOURCES
METHODS
Targeted search was conducted in PubMed using ((monkeypox virus) OR (Orthopoxvirus)) AND (zoonosis)) OR ((monkeypox) OR (human mpox).
CONTENT
BACKGROUND
Forty-seven references were considered that included three publicly available data reports and/or press releases, one book chapter, and 44 published manuscripts.
IMPLICATIONS
CONCLUSIONS
Although zoonosis has been historically linked to emergence events in humans, epidemiological analyses of more recent outbreaks have identified increasing frequencies of human-to-human transmission. Furthermore, viral transmission during the 2022 global human mpox outbreak, caused by a recently identified MPXV subclade, has relied exclusively on human-to-human contact with no known zoonotic link.
Identifiants
pubmed: 37507009
pii: S1198-743X(23)00337-3
doi: 10.1016/j.cmi.2023.07.011
pii:
doi:
Substances chimiques
Virulence Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1502-1507Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.