Effect of acupuncture on episodic memory for amnesia-type mild cognitive impairment: study protocol of a multicenter, randomized, controlled trial.
Acupuncture
Amnesic mild cognitive impairment
Episodic memory
Protocol
Randomized controlled trial
Journal
BMC complementary medicine and therapies
ISSN: 2662-7671
Titre abrégé: BMC Complement Med Ther
Pays: England
ID NLM: 101761232
Informations de publication
Date de publication:
28 Jul 2023
28 Jul 2023
Historique:
received:
23
08
2022
accepted:
26
06
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
28
7
2023
Statut:
epublish
Résumé
Amnesic mild cognitive impairment (aMCI) is the main subtype of mild cognitive impairment (MCI) and has the highest risk of conversion to Alzheimer's disease (AD) among all MCI subtypes. Episodic memory impairment is the early cognitive impairment of aMCI, which has become an important target for AD prevention. Previous clinical evidence has shown that acupuncture can improve the cognitive ability of MCI patients. This experiment aimed to observe the efficacy and neural mechanism of TiaoshenYizhi acupuncture on the episodic memory of patients with aMCI. In this multicenter, parallel-group, double-blind, randomized controlled trial, 360 aMCI participants will be recruited from six subcenters and randomly assigned to the acupuncture group, sham acupuncture group, and control group. The acupuncture group will receive TiaoshenYizhi (TSYZ) acupuncture, the sham acupuncture group will use streitberger sham acupuncture, and the control group will only receive free health education. Participants in the two acupuncture groups will receive real acupuncture treatment or placebo acupuncture three times per week, 24 sessions over 8 consecutive weeks. The primary outcome will be global cognitive ability. Secondary outcomes will be a specific cognitive domain, including episodic memory and execution ability, electroencephalogram, and functional magnetic resonance imaging data. Outcomes will be measured at baseline and the fourth and eighth weeks after randomization. Repeated measurement analysis of variance and a mixed linear model will be used to observe the intervention effect. The protocol will give a detailed procedure to the multicenter clinical trial to further evaluate the efficacy and neural mechanism of TiaoshenYizhi acupuncture on episodic memory in patients with aMCI. From this research, we expect to provide clinical evidence for early aMCI management. http://www.chictr.org.cn/edit.aspx?pid=142612&htm=4 , identifier: ChiCTR2100054009.
Sections du résumé
BACKGROUND
BACKGROUND
Amnesic mild cognitive impairment (aMCI) is the main subtype of mild cognitive impairment (MCI) and has the highest risk of conversion to Alzheimer's disease (AD) among all MCI subtypes. Episodic memory impairment is the early cognitive impairment of aMCI, which has become an important target for AD prevention. Previous clinical evidence has shown that acupuncture can improve the cognitive ability of MCI patients. This experiment aimed to observe the efficacy and neural mechanism of TiaoshenYizhi acupuncture on the episodic memory of patients with aMCI.
METHODS
METHODS
In this multicenter, parallel-group, double-blind, randomized controlled trial, 360 aMCI participants will be recruited from six subcenters and randomly assigned to the acupuncture group, sham acupuncture group, and control group. The acupuncture group will receive TiaoshenYizhi (TSYZ) acupuncture, the sham acupuncture group will use streitberger sham acupuncture, and the control group will only receive free health education. Participants in the two acupuncture groups will receive real acupuncture treatment or placebo acupuncture three times per week, 24 sessions over 8 consecutive weeks. The primary outcome will be global cognitive ability. Secondary outcomes will be a specific cognitive domain, including episodic memory and execution ability, electroencephalogram, and functional magnetic resonance imaging data. Outcomes will be measured at baseline and the fourth and eighth weeks after randomization. Repeated measurement analysis of variance and a mixed linear model will be used to observe the intervention effect.
DISCUSSION
CONCLUSIONS
The protocol will give a detailed procedure to the multicenter clinical trial to further evaluate the efficacy and neural mechanism of TiaoshenYizhi acupuncture on episodic memory in patients with aMCI. From this research, we expect to provide clinical evidence for early aMCI management.
TRIAL REGISTRATION
BACKGROUND
http://www.chictr.org.cn/edit.aspx?pid=142612&htm=4 , identifier: ChiCTR2100054009.
Identifiants
pubmed: 37507779
doi: 10.1186/s12906-023-04059-9
pii: 10.1186/s12906-023-04059-9
pmc: PMC10375685
doi:
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
268Subventions
Organisme : National Natural Science Foundation of China
ID : 81973922
Organisme : Science, Technology and Innovation Commission of Shenzhen Municipality
ID : No.JCYJ20190809151013581
Informations de copyright
© 2023. The Author(s).
Références
Neurobiol Aging. 2019 Dec;84:1-8
pubmed: 31479859
Aging Ment Health. 2020 Sep;24(9):1496-1504
pubmed: 30990085
Front Aging Neurosci. 2020 Jun 05;12:121
pubmed: 32581760
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Zhongguo Zhen Jiu. 2022 Jan 12;42(1):99-103
pubmed: 35025165
Altern Ther Health Med. 2022 Apr 15;:
pubmed: 35427233
Int J Environ Res Public Health. 2021 Jun 25;18(13):
pubmed: 34202299
Lancet. 2021 Apr 24;397(10284):1577-1590
pubmed: 33667416
Chin Med J (Engl). 2012 Aug;125(15):2694-700
pubmed: 22931977
Psicothema. 2019 Feb;31(1):60-65
pubmed: 30664412
Psychiatry Res. 2012 Dec 30;200(2-3):807-12
pubmed: 22520853
Neural Regen Res. 2017 Feb;12(2):250-258
pubmed: 28400807
Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):253-9
pubmed: 19812468
Neural Regen Res. 2014 Jun 1;9(11):1163-8
pubmed: 25206776
Brain. 2010 Feb;133(Pt 2):540-56
pubmed: 19889717
Lancet. 1998 Aug 1;352(9125):364-5
pubmed: 9717924
Auton Neurosci. 2010 Oct 28;157(1-2):81-90
pubmed: 20494627
J Evid Based Med. 2010 Aug;3(3):140-55
pubmed: 21349059
Evid Based Complement Alternat Med. 2013;2013:127271
pubmed: 24023568
Lancet Public Health. 2020 Dec;5(12):e661-e671
pubmed: 33271079
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:4017-4020
pubmed: 28269166
Front Aging Neurosci. 2016 Nov 07;8:260
pubmed: 27872591
BMC Geriatr. 2021 Jan 6;21(1):10
pubmed: 33407219
Med Care. 1992 Jun;30(6):473-83
pubmed: 1593914
Brain Res. 2010 Feb 22;1315:111-8
pubmed: 20025853
Psychiatry Res Neuroimaging. 2018 Dec 30;282:73-81
pubmed: 30419408
Psychogeriatrics. 2020 Mar;20(2):212-228
pubmed: 31808989
Evid Based Complement Alternat Med. 2021 Dec 06;2021:8820705
pubmed: 34912467
J Magn Reson Imaging. 2011 Jan;33(1):33-40
pubmed: 21182118
J Am Geriatr Soc. 2018 Jan;66(1):92-99
pubmed: 29135021
Arch Phys Med Rehabil. 2017 Feb;98(2):249-255.e2
pubmed: 27475119
J Clin Epidemiol. 2005 Aug;58(8):815-22
pubmed: 16018917
Ann Intern Med. 2013 Feb 5;158(3):200-7
pubmed: 23295957
Clin Geriatr Med. 2017 Aug;33(3):325-337
pubmed: 28689566
Magn Reson Imaging. 2012 Jun;30(5):672-82
pubmed: 22459434
Neuroimage Clin. 2014 Feb 27;4:473-80
pubmed: 24634833
Behav Brain Funct. 2012 Jun 07;8:29
pubmed: 22676227
Brain. 2019 Jan 1;143(1):289-302
pubmed: 31746986
Neurology. 2003 Aug 26;61(4):438-44
pubmed: 12939414
J Int Med Res. 2009 Jul-Aug;37(4):1184-90
pubmed: 19761703
Front Aging Neurosci. 2019 Aug 30;11:237
pubmed: 31543811
Brain Sci. 2020 Dec 14;10(12):
pubmed: 33327627
J Intern Med. 2004 Sep;256(3):240-6
pubmed: 15324367
JAMA. 2014 Dec 17;312(23):2551-61
pubmed: 25514304
BMC Complement Altern Med. 2019 Jan 8;19(1):13
pubmed: 30621676
Front Psychiatry. 2020 Feb 28;11:75
pubmed: 32184742
Acupunct Med. 2007 Jun;25(1-2):36-40
pubmed: 17641566