Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Obese Patients.
antibiotics
antifungals
dosage
obesity
pharmacokinetics/pharmacodynamics
therapeutic drug monitoring
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
24 Jun 2023
24 Jun 2023
Historique:
received:
10
05
2023
revised:
14
06
2023
accepted:
21
06
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Obesity is a significant global public health concern that is associated with an elevated risk of comorbidities as well as severe postoperative and nosocomial infections. The treatment of infections in critically ill obese patients can be challenging because obesity affects the pharmacokinetics and pharmacodynamics of antibiotics, leading to an increased risk of antibiotic therapy failure and toxicity due to inappropriate dosages. Precision dosing of antibiotics using therapeutic drug monitoring may help to improve the management of this patient population. This narrative review outlines the pharmacokinetic and pharmacodynamic changes that result from obesity and provides a comprehensive critical review of the current available data on dosage adjustment of antibiotics in critically ill obese patients.
Identifiants
pubmed: 37508195
pii: antibiotics12071099
doi: 10.3390/antibiotics12071099
pmc: PMC10376599
pii:
doi:
Types de publication
Journal Article
Langues
eng
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