Discovery of Novel Myristic Acid Derivatives as N-Myristoyltransferase Inhibitors: Design, Synthesis, Analysis, Computational Studies and Antifungal Activity.
ADMET studies
N-Myristoyltransferase inhibitors
NMT inhibition assay
antifungal activity
molecular docking
myristic acid derivatives
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
09 Jul 2023
09 Jul 2023
Historique:
received:
13
06
2023
revised:
03
07
2023
accepted:
05
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
In recent years, N-Myristoyltransferase (NMT) has been identified as a new target for the treatment of fungal infections. It is observed that at present, there are increased rates of morbidity and mortality due to fungal infections. Hence, a series of novel myristic acid derivatives were designed via molecular docking studies and ADMET studies by targeting NMT (N-Myristoyltransferase). The designed myristic acid derivatives were synthesized by converting myristic acid into myristoyl chloride and coupling it with aryl amines to yield corresponding myristic acid derivatives. The compounds were purified and characterized via FTIR, NMR and HRMS spectral analyses. In this study, we carried out a target NMT inhibition assay. In the NMT screening assay results, the compounds
Identifiants
pubmed: 37508263
pii: antibiotics12071167
doi: 10.3390/antibiotics12071167
pmc: PMC10376843
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : King Khalid University
ID : RGP-1/57/44
Références
Bioorg Med Chem Lett. 2003 Jan 6;13(1):87-91
pubmed: 12467623
Bioorg Med Chem Lett. 2001 Jul 23;11(14):1833-7
pubmed: 11459642
J Biol Chem. 2001 Oct 26;276(43):39501-4
pubmed: 11527981
Nat Commun. 2020 Feb 28;11(1):1132
pubmed: 32111831
J Cell Biol. 1992 May;117(3):515-29
pubmed: 1572893
J Biol Chem. 1994 Jan 28;269(4):2996-3009
pubmed: 8300631
Clin Infect Dis. 2016 Feb 15;62(4):e1-50
pubmed: 26679628
J Med Chem. 1995 May 26;38(11):1837-40
pubmed: 7783114
J Biol Chem. 1993 Mar 5;268(7):4889-902
pubmed: 8444867
J Biol Chem. 1991 May 25;266(15):9732-9
pubmed: 2033063
J Antibiot (Tokyo). 2018 Nov;71(12):978-991
pubmed: 30242283
Bioorg Med Chem Lett. 2002 Feb 25;12(4):607-10
pubmed: 11844682
Vet Res. 2010 Jan-Feb;41(1):9
pubmed: 19796608
Adv Enzyme Regul. 1999;39:175-203
pubmed: 10470373
J Food Sci Technol. 2014 Oct;51(10):2289-303
pubmed: 25328170
J Comput Chem. 2003 Oct;24(13):1549-62
pubmed: 12925999
Eur J Med Chem. 2023 Oct 5;258:115550
pubmed: 37336067
Chem Biol. 2002 Oct;9(10):1119-28
pubmed: 12401496
Bioorg Med Chem Lett. 2006 Jun 1;16(11):3023-9
pubmed: 16554156
Anal Biochem. 2012 Feb 1;421(1):342-4
pubmed: 22051857
PLoS One. 2018 Mar 26;13(3):e0194612
pubmed: 29579063
ACS Chem Biol. 2015 Jun 19;10(6):1425-34
pubmed: 25706802
ACS Infect Dis. 2020 May 8;6(5):768-786
pubmed: 31550886
ACS Infect Dis. 2019 Jan 11;5(1):111-122
pubmed: 30380837
BMC Genomics. 2004 Jun 17;5(1):37
pubmed: 15202951
Expert Rev Anti Infect Ther. 2015 Jun;13(6):787-98
pubmed: 25843556
Molecules. 2016 Nov 29;21(12):
pubmed: 27916844
J Biol Chem. 1991 May 15;266(14):8835-55
pubmed: 2026598
Front Immunol. 2017 Jun 30;8:751
pubmed: 28713376
J Biol Chem. 1991 May 15;266(14):8647-50
pubmed: 2026581
J Med Chem. 1997 May 9;40(10):1422-38
pubmed: 9154965
J Med Chem. 2003 Aug 14;46(17):3572-80
pubmed: 12904062
Biochem J. 1993 Mar 1;290 ( Pt 2):405-10
pubmed: 8452528
Arch Pharm (Weinheim). 1996 Nov;329(11):475-82
pubmed: 8997896
J Med Chem. 1997 Aug 1;40(16):2609-25
pubmed: 9258368
ACS Infect Dis. 2019 Aug 9;5(8):1376-1384
pubmed: 31070884
PLoS Negl Trop Dis. 2014 Sep 04;8(9):e3145
pubmed: 25188325
Mycopathologia. 2008 Aug;166(2):93-102
pubmed: 18443921
Biol Pharm Bull. 2005 Apr;28(4):591-5
pubmed: 15802792
PLoS One. 2018 Nov 14;13(11):e0206355
pubmed: 30427857
Biochemistry. 1990 Nov 20;29(46):10566-73
pubmed: 2271666
Cell Signal. 1997 Jan;9(1):15-35
pubmed: 9067626
Heliyon. 2018 Oct 17;4(10):e00861
pubmed: 30364571