Intercorrelation of Molecular Biomarkers and Clinical Phenotype Measures in Fragile X Syndrome.

Humans Fragile X Syndrome / diagnosis Fragile X Mental Retardation Protein / genetics Phenotype Biomarkers RNA, Messenger / metabolism
FMR1 mRNA FMRP MMP9 clinical trial fragile X syndrome outcome measures

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
24 07 2023
Historique:
received: 18 05 2023
revised: 05 07 2023
accepted: 13 07 2023
medline: 31 7 2023
pubmed: 29 7 2023
entrez: 29 7 2023
Statut: epublish

Résumé

This study contributes to a greater understanding of the utility of molecular biomarkers to identify clinical phenotypes of fragile X syndrome (FXS). Correlations of baseline clinical trial data (molecular measures-

Identifiants

DOI: 10.3390/cells12141920 PMID: 37508583 PMC: PMC10377864
pubmed: 37508583
pii: cells12141920
doi: 10.3390/cells12141920
pmc: PMC10377864
pii:
doi:

Substances chimiques

Fragile X Mental Retardation Protein 139135-51-6
Biomarkers 0
RNA, Messenger 0
FMR1 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD103526
Pays : United States
Organisme : NICHD NIH HHS
ID : NICHD P50 HD103526
Pays : United States

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Auteurs

Ramkumar Aishworiya (R)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore 119074, Singapore.
Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
ORCID: 0000-0002-5749-1248

Mei-Hung Chi (MH)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Psychiatry, National Cheng Kung University Hospital, Tainan 704, Taiwan.

Marwa Zafarullah (M)

Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
ORCID: 0000-0003-1856-0535

Guadalupe Mendoza (G)

Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Matthew Dominic Ponzini (MD)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Kyoungmi Kim (K)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Hazel Maridith Barlahan Biag (HMB)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Angela John Thurman (AJ)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Leonard Abbeduto (L)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
ORCID: 0000-0002-2311-7194

David Hessl (D)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Jamie Leah Randol (JL)

Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
Integrative Genetics and Genomics Graduate Group, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
UC Davis Biotechnology Program, University of California Davis, Davis, CA 95616, USA.

Francois V Bolduc (FV)

Department of Pediatrics, Department of Medical Genetics, Women and Children Health Research Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Sebastien Jacquemont (S)

CHU Sainte-Justine Research Center, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Department of Pediatrics, University of Montreal, Montreal, QC H3T 1J4, Canada.

Sarah Lippé (S)

CHU Sainte-Justine Research Center, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Department of Psychology, Université de Montréal, Montreal, QC H3T 1J4, Canada.

Paul Hagerman (P)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Randi Hagerman (R)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
ORCID: 0000-0001-5029-8448

Andrea Schneider (A)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
ORCID: 0000-0002-4674-7244

Flora Tassone (F)

MIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intercorrelation of Molecular Biomarkers and...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies neurodégénératives héréditaires › Retard mental lié à l'X › Syndrome du chromosome X fragile › Intercorrelation of Molecular Biomarkers and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéine du syndrome X fragile › Intercorrelation of Molecular Biomarkers and...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Intercorrelation of Molecular Biomarkers and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Intercorrelation of Molecular Biomarkers and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Intercorrelation of Molecular Biomarkers and...