Assessment of Colorectal Cancer Risk Factors through the Application of Network-Based Approaches in a Racially Diverse Cohort of Colon Organoid Stem Cells.

WGCNA aging body mass index colon organoid colorectal cancer risk network analysis racial disparities smoking stem cell

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
09 Jul 2023
Historique:
received: 20 04 2023
revised: 03 07 2023
accepted: 07 07 2023
medline: 29 7 2023
pubmed: 29 7 2023
entrez: 29 7 2023
Statut: epublish

Résumé

Numerous demographic factors have been associated with colorectal cancer (CRC) risk. To better define biological mechanisms underlying these associations, we performed RNA sequencing of stem-cell-enriched organoids derived from the healthy colons of seven European Americans and eight African Americans. A weighted gene co-expression network analysis was performed following RNA sequencing. Module-trait relationships were determined through the association testing of each module and five CRC risk factors (age, body mass index, sex, smoking history, and race). Only modules that displayed a significantly positive correlation for gene significance and module membership were considered for further investigation. In total, 16 modules were associated with known CRC risk factors (

Identifiants

pubmed: 37509213
pii: cancers15143550
doi: 10.3390/cancers15143550
pmc: PMC10377524
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIH HHS
ID : NIH/NCI R01 CA143237
Pays : United States
Organisme : NIH HHS
ID : NIH/NCI R01 CA204279
Pays : United States
Organisme : NCI NIH HHS
ID : P20 CA233216
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA044579
Pays : United States

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Auteurs

Matthew Devall (M)

Department of Family Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Stephen Eaton (S)

Department of Family Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Cynthia Yoshida (C)

Digestive Health Center, University of Virginia, Charlottesville, VA 22903, USA.

Steven M Powell (SM)

Digestive Health Center, University of Virginia, Charlottesville, VA 22903, USA.

Graham Casey (G)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA.

Li Li (L)

Department of Family Medicine, University of Virginia, Charlottesville, VA 22903, USA.
University of Virginia Comprehensive Cancer Center, University of Virginia, Charlottesville, VA 22908, USA.

Classifications MeSH