Assessment of Colorectal Cancer Risk Factors through the Application of Network-Based Approaches in a Racially Diverse Cohort of Colon Organoid Stem Cells.
WGCNA
aging
body mass index
colon organoid
colorectal cancer risk
network analysis
racial disparities
smoking
stem cell
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
09 Jul 2023
09 Jul 2023
Historique:
received:
20
04
2023
revised:
03
07
2023
accepted:
07
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Numerous demographic factors have been associated with colorectal cancer (CRC) risk. To better define biological mechanisms underlying these associations, we performed RNA sequencing of stem-cell-enriched organoids derived from the healthy colons of seven European Americans and eight African Americans. A weighted gene co-expression network analysis was performed following RNA sequencing. Module-trait relationships were determined through the association testing of each module and five CRC risk factors (age, body mass index, sex, smoking history, and race). Only modules that displayed a significantly positive correlation for gene significance and module membership were considered for further investigation. In total, 16 modules were associated with known CRC risk factors (
Identifiants
pubmed: 37509213
pii: cancers15143550
doi: 10.3390/cancers15143550
pmc: PMC10377524
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : NIH/NCI R01 CA143237
Pays : United States
Organisme : NIH HHS
ID : NIH/NCI R01 CA204279
Pays : United States
Organisme : NCI NIH HHS
ID : P20 CA233216
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA044579
Pays : United States
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