Circulating Natural Killer Cells as Prognostic Value for Non-Small-Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors: Correlation with Sarcopenia.
immune checkpoint inhibitors (ICIs)
lung cancer
natural killer (NK) cells
non-small-cell lung cancer (NSCLC)
peripheral blood mononuclear cells (PBMCs)
sarcopenia
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 Jul 2023
12 Jul 2023
Historique:
received:
13
06
2023
revised:
05
07
2023
accepted:
10
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of tumors. Natural killer (NK) cells can play an important role in cancer immune surveillance. The aim of this prospective observational study was to analyze peripheral blood mononuclear cells (PBMCs) in patients with advanced non-small-cell lung cancer (NSCLC) receiving ICIs in order to identify predictive factors for better survival outcomes. Forty-seven stage IV NSCLC patients were enrolled. Patients underwent baseline (T Basal levels of CD3 Peripheral NK cells could represent a non-invasive and useful tool to predict ICI therapy response in NSCLC patients, and the association of low NK cell levels with sarcopenia deserves even more attention in clinical evaluation.
Sections du résumé
BACKGROUND
BACKGROUND
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of tumors. Natural killer (NK) cells can play an important role in cancer immune surveillance. The aim of this prospective observational study was to analyze peripheral blood mononuclear cells (PBMCs) in patients with advanced non-small-cell lung cancer (NSCLC) receiving ICIs in order to identify predictive factors for better survival outcomes.
METHODS
METHODS
Forty-seven stage IV NSCLC patients were enrolled. Patients underwent baseline (T
RESULTS
RESULTS
Basal levels of CD3
CONCLUSIONS
CONCLUSIONS
Peripheral NK cells could represent a non-invasive and useful tool to predict ICI therapy response in NSCLC patients, and the association of low NK cell levels with sarcopenia deserves even more attention in clinical evaluation.
Identifiants
pubmed: 37509255
pii: cancers15143592
doi: 10.3390/cancers15143592
pmc: PMC10377538
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Education, Universities and Research
ID : Prot. 2020FYCCE3
Organisme : Ministry of Health
ID : NET-2018-12365454
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