Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series.
enzyme replacement therapy
gene therapy
isoniazid
newborn screening
rifampin
tuberculosis
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
24 Jun 2023
24 Jun 2023
Historique:
received:
15
05
2023
revised:
20
06
2023
accepted:
21
06
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Vaccination with Bacillus Calmette-Guérin (BCG) can be harmful to patients with combined primary immunodeficiencies. We report the outcome of BCG vaccination in a series of twelve patients affected by adenosine deaminase deficiency (ADA-SCID). BCG vaccination resulted in a very high incidence of complications due to uncontrolled replication of the mycobacterium. All patients who developed BCG-related disease were treated successfully and remained free from recurrence of disease. We recommend the prompt initiation of enzyme replacement therapy and secondary prophylaxis to reduce the risk of BCG-related complications in ADA-SCID patients.
Identifiants
pubmed: 37509449
pii: biomedicines11071809
doi: 10.3390/biomedicines11071809
pmc: PMC10376767
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Telethon Foundation
ID : institutional core grant
Références
Blood. 2022 Aug 18;140(7):685-705
pubmed: 35671392
J Allergy Clin Immunol. 2014 Apr;133(4):1134-41
pubmed: 24679470
N Engl J Med. 2009 Jan 29;360(5):447-58
pubmed: 19179314
Haematologica. 2021 Feb 01;106(2):641-646
pubmed: 32817285
Nat Commun. 2022 Mar 14;13(1):1315
pubmed: 35288539
Wkly Epidemiol Rec. 2018 Feb 23;93(8):73-96
pubmed: 29474026
Blood. 2016 Jul 7;128(1):45-54
pubmed: 27129325
BMJ Open. 2022 Nov 21;12(11):e063872
pubmed: 36410811
J Allergy Clin Immunol. 2021 Feb;147(2):417-426
pubmed: 33551023
J Clin Immunol. 2020 May;40(4):625-636
pubmed: 32377975
Lancet Infect Dis. 2017 Mar;17(3):285-295
pubmed: 27964822
Clin Infect Dis. 2006 Feb 15;42(4):548-58
pubmed: 16421800
BMJ Glob Health. 2022 Jan;7(1):
pubmed: 35039309
Lancet Glob Health. 2022 Feb;10(2):e207-e215
pubmed: 34895517
PLoS Med. 2011 Mar;8(3):e1001012
pubmed: 21445325
Lancet Glob Health. 2022 Sep;10(9):e1307-e1316
pubmed: 35961354
J Clin Immunol. 2022 Jan;42(1):195-198
pubmed: 34622389
Haematologica. 2015 Jul;100(7):978-88
pubmed: 26022711
N Engl J Med. 2019 Mar 14;380(11):1001-1011
pubmed: 30865794