Lipoprotein(a) As a Potential Predictive Factor for Earlier Aortic Valve Replacement in Patients with Bicuspid Aortic Valve.
AVS
BAV
Lp(a)
aortic valve stenosis
autotaxin
bicuspid aortic valve
cardiovascular disease
lipid profile parameters
lipoprotein(a)
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
25 Jun 2023
25 Jun 2023
Historique:
received:
24
05
2023
revised:
16
06
2023
accepted:
23
06
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Bicuspid aortic valve (BAV) affects 0.5-2% of the general population and constitutes the major cause of severe aortic valve stenosis (AVS) in individuals ≤70 years. The aim of the present study was to evaluate the parameters that may provide information about the risk of AVS developing in BAV patients, with particular emphasis on lipoprotein(a) (Lp(a)), which is a well-recognized risk factor for stenosis in the general population. We also analyzed the impact of autotaxin (ATX) and interleukin-6 (IL-6) as parameters potentially related to the pathomechanism of Lp(a) action. We found that high Lp(a) levels (>50 mg/dL) occurred significantly more frequently in patients with AVS than in patients without AVS, both in the group below and above 45 years of age (
Identifiants
pubmed: 37509461
pii: biomedicines11071823
doi: 10.3390/biomedicines11071823
pmc: PMC10376971
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Gdańsk Medical University
ID : 01-0520/08/524(01-50022)
Organisme : Gdańsk Medical University
ID : ST 01-50023/0004938
Organisme : National Centre for Research and Development
ID : POWR.03.05.00-00-z082/18
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