Biomechanics of Chondrocytes and Chondrons in Healthy Conditions and Osteoarthritis: A Review of the Mechanical Characterisations at the Microscale.
biomechanical behaviour
biomechanics
cartilage
chondrocyte
chondron
osteoarthritis
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
08 Jul 2023
08 Jul 2023
Historique:
received:
29
05
2023
revised:
05
07
2023
accepted:
06
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Biomechanical studies are expanding across a variety of fields, from biomedicine to biomedical engineering. From the molecular to the system level, mechanical stimuli are crucial regulators of the development of organs and tissues, their growth and related processes such as remodelling, regeneration or disease. When dealing with cell mechanics, various experimental techniques have been developed to analyse the passive response of cells; however, cell variability and the extraction process, complex experimental procedures and different models and assumptions may affect the resulting mechanical properties. For these purposes, this review was aimed at collecting the available literature focused on experimental chondrocyte and chondron biomechanics with direct connection to their biochemical functions and activities, in order to point out important information regarding the planning of an experimental test or a comparison with the available results. In particular, this review highlighted (i) the most common experimental techniques used, (ii) the results and models adopted by different authors, (iii) a critical perspective on features that could affect the results and finally (iv) the quantification of structural and mechanical changes due to a degenerative pathology such as osteoarthritis.
Identifiants
pubmed: 37509581
pii: biomedicines11071942
doi: 10.3390/biomedicines11071942
pmc: PMC10377681
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : PRIN
ID : 20177TTP3S
Organisme : PRIN
ID : 2017HFPKZY
Organisme : PRIN
ID : 20209F3A37
Organisme : BIRD 2022 to E.B.
ID : DOR 2022
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