Role of

HNFA1 gene HbA1c beta cell function glycaemic control

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
10 Jul 2023
Historique:
received: 05 06 2023
revised: 30 06 2023
accepted: 05 07 2023
medline: 29 7 2023
pubmed: 29 7 2023
entrez: 29 7 2023
Statut: epublish

Résumé

The HNF1A transcription factor, implicated in the regulation of pancreatic beta cells, as well as in glucose and lipid metabolism, is responsible for type 3 maturity-onset diabetes of the young (MODY3). HNF1A is also involved in increased susceptibility to polygenic forms of diabetes, such as type 2 diabetes (T2D) and gestational diabetes (GD), while its possible role in type 1 diabetes (T1D) is not known. In this study, 277 children and adolescents with T1D and 140 healthy controls were recruited. The following SNPs in

Identifiants

pubmed: 37509590
pii: biomedicines11071951
doi: 10.3390/biomedicines11071951
pmc: PMC10377126
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : This work was supported by the Ministry of Health, Roma - Italy, in collaboration with the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste - Italy
ID : GR-2019-12369573 to AR, RC 26/22 to AR and RC 06/23 to EC
Organisme : KD and TB were funded in part by the Slovenian Research and Innovation Agency
ID : P3-0343

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Auteurs

Antonietta Robino (A)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 34137 Trieste, Italy.

Gianluca Tornese (G)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 34137 Trieste, Italy.

Davide Tinti (D)

Center for Pediatric Diabetology, A.O.U. Città della Salute e della Scienza, 10126 Torino, Italy.

Klemen Dovc (K)

Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Department of Endocrinology, Diabetes and Metabolism, University Children's Hospital, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.

Valeria Castorani (V)

Department of Pediatrics, IRCCS San Raffaele Hospital, Diabetes Research Institute, 20132 Milano, Italy.

Andrea Conti (A)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 34137 Trieste, Italy.

Roberto Franceschi (R)

Division of Pediatrics, S. Chiara General Hospital, APSS, 38122 Trento, Italy.

Ivana Rabbone (I)

Division of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.

Riccardo Bonfanti (R)

Department of Pediatrics, IRCCS San Raffaele Hospital, Diabetes Research Institute, 20132 Milano, Italy.

Tadej Battelino (T)

Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Department of Endocrinology, Diabetes and Metabolism, University Children's Hospital, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.

Eulalia Catamo (E)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 34137 Trieste, Italy.

Classifications MeSH