Niclosamide Attenuates Inflammation-Associated Profibrotic Responses in Human Subepithelial Lung Myofibroblasts.
collagen
inflammation
myofibroblasts
niclosamide
pulmonary fibrosis
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
19 Jul 2023
19 Jul 2023
Historique:
received:
21
06
2023
revised:
14
07
2023
accepted:
18
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Niclosamide is a commonly used helminthicidic drug for the treatment of human parasitosis by helminths. Recently, efforts have been focusing on repurposing this drug for the treatment of other diseases, such as idiopathic pulmonary fibrosis. Subepithelial lung myofibroblasts (SELMs) isolated from tissue biopsies of patients undergoing surgery for lung cancer were stimulated with TNF-α (50 ng/mL), IL-1α (5 ng/mL), added alone or in combination, and TGF-β
Identifiants
pubmed: 37509671
pii: biomedicines11072032
doi: 10.3390/biomedicines11072032
pmc: PMC10377180
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : "Establishment of a Center of Excellence for Pharmacological Studies and Precision Medicine - IMPReS" (MIS 5047189) which is implemented under the Action "Support for Regional Excellence", funded by the Operational Program "Competitiveness, Entrepreneursh
ID : MIS 5047189
Organisme : «Strategic expansion of the Greek Biobanking Infrastructure» (BBMRI-GR) (MIS 5028275) in the framework of the Action "Enhancing Research and Innovation Infrastructure - Second Cycle"
ID : MIS 5028275
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