EML4-ALK Gene Mutation Detected with New NGS Lung Cancer Panel CDx Using Sputum Cytology in a Case of Advanced NSCLC.
EML4-ALK lung adenocarcinoma
lung cancer compact panel TM
next-generation sequencing
non-small cell lung cancer
sputum cytology
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
10 Jul 2023
10 Jul 2023
Historique:
received:
15
06
2023
revised:
01
07
2023
accepted:
06
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
The detection of driver gene mutations has become essential for lung cancer; however, insufficient sample sizes make gene panel tests difficult to use. We previously reported that the lung cancer compact panel TM (LCCP) could detect EGFR and MET gene mutations with sputum cytology. To date, the detection of gene mutation using RNA from sputum samples is considered practically difficult. We report a case in which the EML4-ALK fusion gene was successfully detected from a sputum sample using the LCCP that was just released in Japan as a new next-generation sequencing lung cancer panel, CDx.
Identifiants
pubmed: 37510070
pii: diagnostics13142327
doi: 10.3390/diagnostics13142327
pmc: PMC10378045
pii:
doi:
Types de publication
Journal Article
Langues
eng
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