Contrast-Enhanced Computed Tomography and Laboratory Parameters as Non-Invasive Diagnostic Markers of Pancreatic Fibrosis.
attenuation
chronic pancreatitis
computed tomography
fibronectin
hyaluronic acid
pancreatic fibrosis
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
21 Jul 2023
21 Jul 2023
Historique:
received:
28
06
2023
revised:
15
07
2023
accepted:
18
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Pancreatic fibrosis (PF) is a part of the pathogenesis in most pancreatic disorders and plays a crucial role in chronic pancreatitis development. The aim of our study was to investigate a relationship between PF grade and signs in resected pancreatic specimens, and the results of both multidetector computed tomography (MDCT) post-processing parameters and fibronectin (FN), hyaluronic acid (HA), matrix metalloproteinase (MMP)-1, and MMP-9 serum levels. The examination results of 74 patients were analyzed. The unenhanced pancreas density (UPD) value and contrast enhancement ratio (CER) showed statistically significant differences in groups with peri- and intralobular fibrosis grades, an integrative index of fibrosis, inflammation in pancreatic tissue, and pancreatic duct epithelium metaplasia, while the normalized contrast enhancement ratio in the venous phase (NCER VP) significantly differed with the perilobular fibrosis grade, integrative fibrosis index, and inflammation (
Identifiants
pubmed: 37510179
pii: diagnostics13142435
doi: 10.3390/diagnostics13142435
pmc: PMC10377847
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The autonomous non-profit organization "Moscow Center for Innovative Technologies in Healthcare" of the Moscow Healthcare Department
ID : 2412-21/22
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