Human Endogenous Retrovirus-H-Derived miR-4454 Inhibits the Expression of
DnaJ heat shock protein family (Hsp40) member B4
HERV-H-derived microRNAs
SAM and SH3 domain containing 1
human endogenous retrovirus
miR-4454
miRNAs derived from transposable elements
non-muscle-invasive bladder cancer
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
07 07 2023
07 07 2023
Historique:
received:
14
06
2023
revised:
04
07
2023
accepted:
06
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Although most human endogenous retroviruses (HERVs) have been silenced and lost their ability to translocate because of accumulated mutations during evolution, they still play important roles in human biology. Several studies have demonstrated that HERVs play pathological roles in numerous human diseases, especially cancer. A few studies have revealed that long non-coding RNAs that are transcribed from HERV sequences affect cancer progression. However, there is no study on microRNAs derived from HERVs related to cancer. In this study, we identified 29 microRNAs (miRNAs) derived from HERV sequences in the human genome. In particular, we discovered that miR-4454, which is HERV-H-derived miRNA, was upregulated in non-muscle-invasive bladder cancer (NMIBC) cells. To figure out the effects of upregulated miR-4454 in NMIBC, genes whose expression was downregulated in NMIBC, as well as tumor suppressor genes, were selected as putative target genes of miR-4454. The dual-luciferase assay was used to determine the negative relationship between miR-4454 and its target genes,
Identifiants
pubmed: 37510314
pii: genes14071410
doi: 10.3390/genes14071410
pmc: PMC10379226
pii:
doi:
Substances chimiques
DNAJB4 protein, human
0
HSP40 Heat-Shock Proteins
0
MicroRNAs
0
SASH1 protein, human
0
Tumor Suppressor Proteins
0
MIRN4454 microRNA, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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