Mutations in Structural Genes of the Mitochondrial Complex IV May Influence Breast Cancer.
breast cancer
complex IV
mitochondria
oxidative phosphorylation
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
18 07 2023
18 07 2023
Historique:
received:
14
06
2023
revised:
13
07
2023
accepted:
17
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Although it has gained more attention in recent years, the relationship between breast cancer (BC) and mitochondrial oxidative phosphorylation (OXPHOS) is still not well understood. Importantly, Complex IV or Cytochrome C Oxidase (COX) of OXPHOS is one of the key players in mitochondrial balance. An in silico investigation of mutations in structural genes of Complex IV was conducted in BC, comprising 2107 samples. Our findings show four variants (rs267606614, rs753969142, rs199476128 and rs267606884) with significant pathogenic potential. Moreover, we highlight nine genes (
Identifiants
pubmed: 37510369
pii: genes14071465
doi: 10.3390/genes14071465
pmc: PMC10379055
pii:
doi:
Substances chimiques
Electron Transport Complex IV
EC 1.9.3.1
Banques de données
figshare
['10.6084/m9.figshare.23260352']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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