The Impact of Persistent Noise Exposure under Inflammatory Conditions.
anxiety-like behavior
blood–brain barrier
cognitive impairment
inflammation
neuroinflammation
noise exposure
Journal
Healthcare (Basel, Switzerland)
ISSN: 2227-9032
Titre abrégé: Healthcare (Basel)
Pays: Switzerland
ID NLM: 101666525
Informations de publication
Date de publication:
19 Jul 2023
19 Jul 2023
Historique:
received:
05
06
2023
revised:
12
07
2023
accepted:
18
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
The aim of this study was to investigate the impact of noise exposure in an intensive care unit (ICU) environment on the development of postoperative delirium in a mouse model that mimics the ICU environment. Additionally, we aimed to identify the underlying mechanisms contributing to delirium and provide evidence for reducing the risk of delirium. In this study, to mimic an ICU environment, lipopolysaccharide (LPS)-injected sepsis mouse models were exposed to a 75 dB noise condition. Furthermore, we assessed neurobehavioral function and observed the level of neuroinflammatory response and blood-brain barrier (BBB) integrity in the hippocampal region. The LPS-injected sepsis mouse model exposed to noise exhibited increased anxiety-like behavior and cognitive impairment. Moreover, severe neuroinflammation and BBB disruption were detected in the hippocampal region. This study provides insights suggesting that persistent noise exposure under systemic inflammatory conditions may cause cognitive dysfunction and anxiety- like behavior via the mediation of BBB disruption and neuroinflammation. As a result, we suggest that the detailed regulation of noise exposure may be required to prevent the development of postoperative delirium.
Identifiants
pubmed: 37510508
pii: healthcare11142067
doi: 10.3390/healthcare11142067
pmc: PMC10379677
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : faculty research grant from Yonsei University College of Medicine
ID : 6-2019-0061
Organisme : Severance Hospital Research fund for Clinical excellence (SHRC)
ID : C-2021-0043
Organisme : National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)
ID : 2022R1C1C100962212
Organisme : Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education
ID : NRF-2020R1A2C1012166
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