An Observational Study to Develop a Predictive Model for Bacterial Pneumonia Diagnosis in Severe COVID-19 Patients-C19-PNEUMOSCORE.

COVID-19 antimicrobial stewardship bacterial co-infection bacterial pneumonia prognostic tool

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
14 Jul 2023
Historique:
received: 18 06 2023
revised: 11 07 2023
accepted: 12 07 2023
medline: 29 7 2023
pubmed: 29 7 2023
entrez: 29 7 2023
Statut: epublish

Résumé

In COVID-19 patients, antibiotics overuse is still an issue. A predictive scoring model for the diagnosis of bacterial pneumonia at intensive care unit (ICU) admission would be a useful stewardship tool. We performed a multicenter observational study including 331 COVID-19 patients requiring invasive mechanical ventilation at ICU admission; 179 patients with bacterial pneumonia; and 152 displaying negative lower-respiratory samplings. A multivariable logistic regression model was built to identify predictors of pulmonary co-infections, and a composite risk score was developed using β-coefficients. We identified seven variables as predictors of bacterial pneumonia: vaccination status (OR 7.01; 95% CI, 1.73-28.39); chronic kidney disease (OR 3.16; 95% CI, 1.15-8.71); pre-ICU hospital length of stay ≥ 5 days (OR 1.94; 95% CI, 1.11-3.4); neutrophils ≥ 9.41 × 10

Identifiants

pubmed: 37510807
pii: jcm12144688
doi: 10.3390/jcm12144688
pmc: PMC10381000
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ministero della Salute
ID : GR-2018-1236737

Références

Clin Infect Dis. 2021 May 18;72(10):e533-e541
pubmed: 32820807
Crit Care. 2022 May 9;26(1):130
pubmed: 35534867
Diagn Microbiol Infect Dis. 2022 Jan;102(1):115558
pubmed: 34731685
Clin Respir J. 2021 Jul;15(7):815-825
pubmed: 33818909
Lancet Respir Med. 2020 Dec;8(12):1201-1208
pubmed: 32861276
Infection. 2023 Feb;51(1):129-136
pubmed: 35687293
Blood. 2022 Jul 21;140(3):236-252
pubmed: 35544585
Infection. 2022 Oct;50(5):1243-1253
pubmed: 35488112
J Clin Epidemiol. 2008 Apr;61(4):344-9
pubmed: 18313558
J Infect. 2022 Oct;85(4):374-381
pubmed: 35781017
Clin Microbiol Infect. 2020 Oct;26(10):1395-1399
pubmed: 32603803
Intensive Care Med. 2020 Sep;46(9):1787-1789
pubmed: 32661615
Am J Respir Crit Care Med. 2021 Sep 1;204(5):546-556
pubmed: 34038699
Intensive Care Med. 1996 Jul;22(7):707-10
pubmed: 8844239
Ann Intensive Care. 2020 Sep 7;10(1):119
pubmed: 32894364
Microbiol Spectr. 2021 Dec 22;9(3):e0069521
pubmed: 34756067
JAC Antimicrob Resist. 2021 Nov 28;3(4):dlab180
pubmed: 34859223
Chest. 2021 Aug;160(2):454-465
pubmed: 33857475
J Med Virol. 2021 Jul;93(7):4564-4569
pubmed: 33822390
Crit Care. 2021 Jun 7;25(1):197
pubmed: 34099016
Clin Infect Dis. 2020 Nov 19;71(16):2174-2179
pubmed: 32445579
Clin Microbiol Infect. 2023 Jun;29(6):734-743
pubmed: 36681325
Lancet Infect Dis. 2022 Sep;22(9):1293-1302
pubmed: 35753318
J Chronic Dis. 1987;40(5):373-83
pubmed: 3558716
Antibiotics (Basel). 2022 Jul 04;11(7):
pubmed: 35884147
J Clin Med. 2022 Dec 04;11(23):
pubmed: 36498781
J Microbiol Immunol Infect. 2022 Dec;55(6 Pt 1):985-992
pubmed: 36243668
Toxins (Basel). 2020 May 06;12(5):
pubmed: 32384617
JAMA Netw Open. 2022 Oct 3;5(10):e2238871
pubmed: 36301541
Clin Infect Dis. 2021 Jan 22;:
pubmed: 33480973
Intensive Care Med. 2021 Jan;47(1):104-106
pubmed: 33068116
Front Public Health. 2022 Sep 12;10:963667
pubmed: 36172213
Clin Microbiol Infect. 2021 Jan;27(1):83-88
pubmed: 32745596
JAMA. 1993 Dec 22-29;270(24):2957-63
pubmed: 8254858
Curr Opin Crit Care. 2018 Oct;24(5):339-346
pubmed: 30028740
Intensive Care Med. 2022 Jun;48(6):690-705
pubmed: 35596752
Int J Antimicrob Agents. 2021 Oct;58(4):106409
pubmed: 34339777
Int J Infect Dis. 2020 Jul;96:291-293
pubmed: 32437939
Curr Opin Pulm Med. 2012 May;18(3):213-21
pubmed: 22388582

Auteurs

Eloisa Sofia Tanzarella (ES)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Joel Vargas (J)

Dipartimento di Scienze Cardiovascolari, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Marco Menghini (M)

U.O.C. Terapia Intensiva OM e Hub Maxi Emergenze, Ospedale Maggiore Carlo Alberto Pizzardi, 40133 Bologna, Italy.

Stefania Postorino (S)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Francesca Pozzana (F)

Dipartimento di Anestesia e Rianimazione, Ospedale Santa Maria Goretti, 04100 Latina, Italy.

Maria Sole Vallecoccia (MS)

Anesthesia and Intensive Care Unit, Department of Emergency and Critical Care, Santa Maria Nuova Hospital, 50122 Florence, Italy.

Francesco Lorenzo De Matteis (FL)

Department of Medical Science, Surgery and Neurosciences, Cardiothoracic and Vascular Anesthesia and Intensive Care Unit, University of Siena, 53100 Siena, Italy.

Federico Franchi (F)

Department of Medical Science, Surgery and Neurosciences, Cardiothoracic and Vascular Anesthesia and Intensive Care Unit, University of Siena, 53100 Siena, Italy.

Amato Infante (A)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Luigi Larosa (L)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Maria Antonietta Mazzei (MA)

Unit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.

Salvatore Lucio Cutuli (SL)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Domenico Luca Grieco (DL)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Alessandra Bisanti (A)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Simone Carelli (S)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Gianmarco Lombardi (G)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Edoardo Piervincenzi (E)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Gabriele Pintaudi (G)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Tommaso Pirronti (T)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Mario Tumbarello (M)

Dipartimento di Biotecnologie Mediche, Università degli Studi di Siena, 53100 Siena, Italy.

Massimo Antonelli (M)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Gennaro De Pascale (G)

Dipartimento di Scienze Dell'emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Classifications MeSH