Glycine: The Smallest Anti-Inflammatory Micronutrient.
glycine
immunomodulator
inflammation
targets
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Jul 2023
08 Jul 2023
Historique:
received:
19
06
2023
accepted:
30
06
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Glycine is a non-essential amino acid with many functions and effects. Glycine can bind to specific receptors and transporters that are expressed in many types of cells throughout an organism to exert its effects. There have been many studies focused on the anti-inflammatory effects of glycine, including its abilities to decrease pro-inflammatory cytokines and the concentration of free fatty acids, to improve the insulin response, and to mediate other changes. However, the mechanism through which glycine acts is not clear. In this review, we emphasize that glycine exerts its anti-inflammatory effects throughout the modulation of the expression of nuclear factor kappa B (NF-κB) in many cells. Although glycine is a non-essential amino acid, we highlight how dietary glycine supplementation is important in avoiding the development of chronic inflammation.
Identifiants
pubmed: 37510995
pii: ijms241411236
doi: 10.3390/ijms241411236
pmc: PMC10379184
pii:
doi:
Substances chimiques
Glycine
TE7660XO1C
Micronutrients
0
Cytokines
0
NF-kappa B
0
Amino Acids
0
Anti-Inflammatory Agents
0
Trace Elements
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto Politécnico Nacional
ID : SIP-IPN-20230866
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