Obacunone Photoprotective Effects against Solar-Simulated Radiation-Induced Molecular Modifications in Primary Keratinocytes and Full-Thickness Human Skin.
full-thickness skin model
obacunone
photodamage
photoprotection
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Jul 2023
14 Jul 2023
Historique:
received:
18
05
2023
revised:
06
07
2023
accepted:
12
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Solar radiation can cause damage to the skin, leading to various adverse effects such as sunburn, reactive oxygen species production, inflammation, DNA damage, and photoaging. To study the potential of photoprotective agents, full-thickness skin models are increasingly being used as in vitro tools. One promising approach to photoprotection involves targeting the redox-sensitive transcription factor Nrf2, which is responsible for regulating various cellular defense mechanisms, including the antioxidant response, inflammatory signaling, and DNA repair. Obacunone, a natural triterpenoid, has been identified as a potent Nrf2 agonist. The present study aims to evaluate the relevance of full-thickness (FT) skin models in photoprotection studies and to explore the potential photoprotective effects of obacunone on those models and in human keratinocytes. Phenion
Identifiants
pubmed: 37511243
pii: ijms241411484
doi: 10.3390/ijms241411484
pmc: PMC10380981
pii:
doi:
Substances chimiques
obacunone
751-03-1
NF-E2-Related Factor 2
0
Radiation-Protective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Innovation
ID : PID2020-114871RB-I00
Organisme : Instituto de Salud Carlos III
ID : PI20/01363 (JM) and CIBERES (CB06/06/0027)
Organisme : Ministry of Science and Innovation
ID : CDTi (ARTSKIN IDI-20190271)
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