Gut Microbiota, Metabolome, and Body Composition Signatures of Response to Therapy in Patients with Advanced Melanoma.
advanced melanoma
body composition
gut microbiota
metabolome
response to therapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Jul 2023
18 Jul 2023
Historique:
received:
23
05
2023
revised:
11
07
2023
accepted:
14
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Despite the recent breakthroughs in targeted and immunotherapy for melanoma, the overall survival rate remains low. In recent years, considerable attention has been paid to the gut microbiota and other modifiable patient factors (e.g., diet and body composition), though their role in influencing therapeutic responses has yet to be defined. Here, we characterized a cohort of 31 patients with unresectable IIIC-IV-stage cutaneous melanoma prior to initiation of targeted or first-line immunotherapy via the following methods: (i) fecal microbiome and metabolome via 16S rRNA amplicon sequencing and gas chromatography/mass spectrometry, respectively, and (ii) anthropometry, body composition, nutritional status, physical activity, biochemical parameters, and immunoprofiling. According to our data, patients subsequently classified as responders were obese (i.e., with high body mass index and high levels of total, visceral, subcutaneous, and intramuscular adipose tissue), non-sarcopenic, and enriched in certain fecal taxa (e.g.,
Identifiants
pubmed: 37511376
pii: ijms241411611
doi: 10.3390/ijms241411611
pmc: PMC10380337
pii:
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Eur J Cancer. 2017 Sep;82:45-55
pubmed: 28648698
ESMO Open. 2022 Dec;7(6):100645
pubmed: 36455507
Nature. 2019 Jan;565(7741):600-605
pubmed: 30675064
mSystems. 2023 Apr 27;8(2):e0102322
pubmed: 36809182
BMC Bioinformatics. 2012 Feb 14;13:31
pubmed: 22333067
Nat Commun. 2020 May 1;11(1):2168
pubmed: 32358520
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Cancer Immunol Res. 2017 Jan;5(1):3-8
pubmed: 28052991
Science. 2018 Jan 5;359(6371):104-108
pubmed: 29302014
Lancet Oncol. 2018 May;19(5):e227-e228
pubmed: 29726386
Cancers (Basel). 2021 Aug 08;13(16):
pubmed: 34439153
J Hematol Oncol. 2022 Apr 29;15(1):47
pubmed: 35488243
Semin Immunol. 2016 Apr;28(2):187-96
pubmed: 27067179
J Natl Cancer Inst. 2014 May 29;106(6):dju124
pubmed: 24875653
Cells. 2023 Mar 02;12(5):
pubmed: 36899926
Cancer. 2020 Feb 1;126(3):575-582
pubmed: 31648379
Science. 2021 Feb 5;371(6529):602-609
pubmed: 33303685
Appl Physiol Nutr Metab. 2008 Oct;33(5):997-1006
pubmed: 18923576
Geroscience. 2020 Feb;42(1):201-216
pubmed: 31808027
Biotechniques. 2004 May;36(5):808-12
pubmed: 15152600
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Oncology. 2022;100(9):498-504
pubmed: 35817000
Curr Oncol Rep. 2019 Jul 1;21(8):72
pubmed: 31263961
Ann Surg Oncol. 2011 Dec;18(13):3579-85
pubmed: 21822551
JCI Insight. 2020 Dec 3;5(23):
pubmed: 33268597
Invest New Drugs. 2017 Aug;35(4):436-441
pubmed: 28396974
Cancer Drug Resist. 2022 May 12;5(2):436-450
pubmed: 35800370
Science. 2021 Dec 24;374(6575):1632-1640
pubmed: 34941392
Molecules. 2021 Jul 24;26(15):
pubmed: 34361625
Nat Med. 2022 Mar;28(3):545-556
pubmed: 35228752
Cancers (Basel). 2022 Jul 13;14(14):
pubmed: 35884452
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
Front Oncol. 2021 Aug 26;11:726257
pubmed: 34513704
Front Microbiol. 2019 Jan 08;9:3113
pubmed: 30671028
Int J Epidemiol. 1997;26 Suppl 1:S152-60
pubmed: 9126543
Cancer Cell. 2018 Apr 9;33(4):570-580
pubmed: 29634945
J Immunol Methods. 2019 Dec;475:112616
pubmed: 31181213
World Health Organ Tech Rep Ser. 1995;854:1-452
pubmed: 8594834
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
Sci Rep. 2021 Jun 22;11(1):13087
pubmed: 34158560
Ann Oncol. 2016 Apr;27(4):732-8
pubmed: 26802161
Int J Cancer. 2013 Mar 15;132(6):1404-11
pubmed: 22821300
Horm Metab Res. 1996 Dec;28(12):690-3
pubmed: 9013743
Anticancer Agents Med Chem. 2018;18(2):216-236
pubmed: 28745237
Genome Med. 2021 Oct 13;13(1):160
pubmed: 34641962
PLoS One. 2023 Feb 10;18(2):e0277708
pubmed: 36763597
Int J Behav Nutr Phys Act. 2011 Oct 21;8:115
pubmed: 22018588
J Dermatol Sci. 2016 Dec;84(3):305-313
pubmed: 27712859
Obes Rev. 2022 Oct;23(10):e13498
pubmed: 35856338
Science. 2018 Jan 5;359(6371):97-103
pubmed: 29097493
Science. 2021 Feb 5;371(6529):595-602
pubmed: 33542131
PeerJ. 2016 Oct 18;4:e2584
pubmed: 27781170
N Engl J Med. 2017 Oct 5;377(14):1345-1356
pubmed: 28889792
Front Microbiol. 2016 Dec 02;7:1945
pubmed: 27994578
Int J Mol Sci. 2022 Oct 09;23(19):
pubmed: 36233289
Microorganisms. 2021 Mar 12;9(3):
pubmed: 33808993
Nat Med. 2019 Jan;25(1):141-151
pubmed: 30420753
mSphere. 2023 Feb 21;8(1):e0049022
pubmed: 36507724
Lancet Oncol. 2008 Jul;9(7):629-35
pubmed: 18539529
Lancet Oncol. 2018 Mar;19(3):310-322
pubmed: 29449192
Cell. 2016 Jun 2;165(6):1332-1345
pubmed: 27259147
Food Chem X. 2021 Sep 11;11:100129
pubmed: 34585136
Mech Ageing Dev. 2022 Sep;206:111711
pubmed: 35868543
Nat Biotechnol. 2019 Aug;37(8):852-857
pubmed: 31341288
J Breath Res. 2018 Jan 03;12(2):026001
pubmed: 28952968