Comparison of Efavirenz and Doravirine Developmental Toxicity in an Embryo Animal Model.
HIV
NNRTI
developmental safety
doravirine
efavirenz
non-nucleoside reverse transcriptase inhibitors
zebrafish embryo
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Jul 2023
19 Jul 2023
Historique:
received:
23
06
2023
revised:
11
07
2023
accepted:
18
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
In the past, one of the most widely used non-nucleoside reverse transcriptase inhibitors (NNRTI) in first-line antiretroviral therapy (ART) of HIV infection was efavirenz (EFV), which is already used as a cost-effective treatment in developing countries due to its efficacy, tolerability, and availability. However, EFV also demonstrates several adverse effects, like hepatotoxicity, altered lipid profile, neuropsychological symptoms, and behavioral effects in children after in utero exposure. In 2018, another NNRTI, doravirine (DOR), was approved due to its similar efficacy but better safety profile. Preclinical safety studies demonstrated that DOR is not genotoxic and exhibits no developmental toxicity or effects on fertility in rats. Zebrafish (
Identifiants
pubmed: 37511423
pii: ijms241411664
doi: 10.3390/ijms241411664
pmc: PMC10380689
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
efavirenz
JE6H2O27P8
doravirine
913P6LK81M
Reverse Transcriptase Inhibitors
0
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Brescia
ID : Fondi ex 60%
Références
Angiogenesis. 1999;3(4):353-9
pubmed: 14517415
Expert Opin Drug Saf. 2013 Nov;12(6):841-6
pubmed: 23889591
Eur J Pharmacol. 2017 Mar 15;799:7-15
pubmed: 28188763
BMC Endocr Disord. 2023 Apr 27;23(1):94
pubmed: 37106328
Biomedicines. 2019 Mar 26;7(1):
pubmed: 30917585
Congenit Anom (Kyoto). 2016 Jan;56(1):18-27
pubmed: 26537640
Int J Mol Sci. 2023 Jan 19;24(3):
pubmed: 36768311
Dev Dyn. 2014 Feb;243(2):299-314
pubmed: 24123392
Biochem Pharmacol. 2020 Aug;178:114050
pubmed: 32446887
Lancet HIV. 2020 Jan;7(1):e49-e58
pubmed: 31740351
Front Neurosci. 2023 Mar 02;17:1086462
pubmed: 36937661
JAMA. 2023 Apr 18;329(15):1308-1309
pubmed: 37010862
Clin Infect Dis. 2015 Apr 1;60(7):1026-32
pubmed: 25501988
Int J Mol Sci. 2017 Apr 04;18(4):
pubmed: 28375163
Cell Transplant. 2016 Nov;25(11):1967-1977
pubmed: 28836850
J Hepatol. 2019 May;70(5):930-940
pubmed: 30677459
Lancet HIV. 2020 Jan;7(1):e16-e26
pubmed: 31740348
AIDS. 2002 Jan 25;16(2):299-300
pubmed: 11807320
Life Sci. 2022 Apr 1;294:120329
pubmed: 35090905
Epilepsia. 2019 Feb;60(2):e8-e13
pubmed: 30663052
Oncotarget. 2020 Oct 13;11(41):3737-3748
pubmed: 33110481
Br J Pharmacol. 2010 Aug;160(8):2069-84
pubmed: 20649602
Oncol Rep. 2017 Jan;37(1):617-621
pubmed: 27878300
Br J Pharmacol. 2017 Jul;174(13):1925-1944
pubmed: 28217866
AIDS. 2021 Apr 1;35(5):759-767
pubmed: 33587439
Int J Mol Sci. 2021 May 03;22(9):
pubmed: 34063734
Dev Biol. 2016 Jan 1;409(1):114-128
pubmed: 26477558
AIDS. 2014 Mar;28 Suppl 2:S123-31
pubmed: 24849471
Antivir Ther. 2019;24(6):425-435
pubmed: 31355775
J Acquir Immune Defic Syndr. 2019 Aug 1;81(4):463-472
pubmed: 30985556
Antiviral Res. 2011 Aug;91(2):112-9
pubmed: 21619898
Arch Intern Med. 2002 Feb 11;162(3):355
pubmed: 11822930
Int J Dev Biol. 2017;61(1-2):105-111
pubmed: 28287241
J Antimicrob Chemother. 2008 Aug;62(2):234-45
pubmed: 18480167
J Pharmacol Exp Ther. 2012 Dec;343(3):696-703
pubmed: 22984227
Transl Psychiatry. 2019 Feb 11;9(1):84
pubmed: 30745561
Birth Defects Res. 2023 Mar 1;115(4):430-440
pubmed: 36373861
Neurology. 2011 Apr 19;76(16):1403-9
pubmed: 21502598
Dev Dyn. 1995 Jul;203(3):253-310
pubmed: 8589427
Exp Cell Res. 2015 Oct 1;337(2):160-9
pubmed: 26238601
Medicine (Baltimore). 2022 Jul 29;101(30):e29855
pubmed: 35905209
Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):965-72
pubmed: 18624683
BMC Psychiatry. 2022 Nov 16;22(1):710
pubmed: 36384522
Pharmacol Res. 2016 Aug;110:10-24
pubmed: 27157251
BMC Infect Dis. 2023 Apr 14;23(1):227
pubmed: 37059996
Cancer Res. 2007 Apr 1;67(7):2927-31
pubmed: 17409396
Cancer Biol Ther. 2023 Dec 31;24(1):20-32
pubmed: 36588385
Clin Infect Dis. 2019 Feb 1;68(4):535-544
pubmed: 30184165
AIDS Res Hum Retroviruses. 2022 Nov;38(11):878-880
pubmed: 36166220
Ann Intern Med. 2014 Jul 1;161(1):1-10
pubmed: 24979445
PLoS One. 2015 Jun 18;10(6):e0130277
pubmed: 26086472
Curr Issues Mol Biol. 2022 Jul 27;44(8):3364-3377
pubmed: 36005128
Neurobiol Dis. 2016 Jan;85:35-48
pubmed: 26476142
Pediatr Infect Dis J. 2019 Aug;38(8):828-834
pubmed: 30985518
Biochemistry. 2006 Dec 26;45(51):15179-87
pubmed: 17176039
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18656-61
pubmed: 24167256
AIDS. 2021 Jan 1;35(1):91-99
pubmed: 33048879
Curr HIV Res. 2010 Oct;8(7):545-53
pubmed: 21073442
Dev Biol. 2001 Feb 15;230(2):278-301
pubmed: 11161578
Lab Anim Res. 2021 Sep 8;37(1):26
pubmed: 34496973
AIDS. 2022 Dec 1;36(15):2231-2233
pubmed: 36382442