Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression.
breast cancer
diabetes
gene dysregulation
hyperglycemia
hyperinsulinemia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jul 2023
23 Jul 2023
Historique:
received:
05
07
2023
revised:
19
07
2023
accepted:
20
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Diabetes mellitus is a burdensome disease that affects various cellular functions through altered glucose metabolism. Several reports have linked diabetes to cancer development; however, the exact molecular mechanism of how diabetes-related traits contribute to cancer progression is not fully understood. The current study aimed to explore the molecular mechanism underlying the potential effect of hyperglycemia combined with hyperinsulinemia on the progression of breast cancer cells. To this end, gene dysregulation induced by the exposure of MCF7 breast cancer cells to hyperglycemia (HG), or a combination of hyperglycemia and hyperinsulinemia (HGI), was analyzed using a microarray gene expression assay. Hyperglycemia combined with hyperinsulinemia induced differential expression of 45 genes (greater than or equal to two-fold), which were not shared by other treatments. On the other hand, in silico analysis performed using a publicly available dataset (GEO: GSE150586) revealed differential upregulation of 15 genes in the breast tumor tissues of diabetic patients with breast cancer when compared with breast cancer patients with no diabetes.
Identifiants
pubmed: 37511575
pii: ijms241411816
doi: 10.3390/ijms241411816
pmc: PMC10380477
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The present study was supported by grants from the University of Sharjah (grants no. 16010901011 and 1801090143), UAE
ID : 16010901011 and 1801090143
Références
Pflugers Arch. 2013 Nov;465(11):1583-97
pubmed: 23733100
Mol Med Rep. 2017 Nov;16(5):6690-6696
pubmed: 28901503
Redox Biol. 2019 Jul;25:101076
pubmed: 30642723
J Biol Chem. 2004 Feb 13;279(7):5059-65
pubmed: 14617629
Steroids. 2018 May;133:8-14
pubmed: 29157917
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
Data Brief. 2016 Sep 22;9:579-584
pubmed: 27761513
PLoS One. 2013 Nov 18;8(11):e79708
pubmed: 24260287
Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):466-70
pubmed: 20473153
Breast J. 2017 Jul;23(4):482-483
pubmed: 28121048
Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):890-9
pubmed: 21430298
Oncotarget. 2018 Jan 9;9(6):6977-6992
pubmed: 29467944
Pediatr Blood Cancer. 2020 Feb;67(2):e28085
pubmed: 31736211
Plast Reconstr Surg. 2017 Sep;140(3):495e
pubmed: 28582336
Nat Commun. 2020 Jul 24;11(1):3715
pubmed: 32709844
Int J Mol Sci. 2021 Aug 28;22(17):
pubmed: 34502254
Indian J Cancer. 2017 Oct-Dec;54(4):652-657
pubmed: 30082552
Am J Clin Nutr. 2002 Jul;76(1):266S-73S
pubmed: 12081850
Cancer Sci. 2020 Mar;111(3):962-973
pubmed: 31960523
Front Oncol. 2020 Jun 16;10:915
pubmed: 32612951
Endocr Rev. 2016 Jun;37(3):278-316
pubmed: 27159875
Anesthesiology. 2008 Jul;109(1):137-48
pubmed: 18580184
Acta Obstet Gynecol Scand. 2013 Feb;92(2):165-71
pubmed: 23072215
Cell Rep. 2017 Nov 28;21(9):2384-2392
pubmed: 29186678
J Cell Physiol. 2015 Jan;230(1):191-8
pubmed: 24931902
Acta Oncol. 2018 Jan;57(1):129-134
pubmed: 29202645
Oncotarget. 2016 Aug 2;7(31):50017-50026
pubmed: 27374181
Clin Obstet Gynecol. 2016 Dec;59(4):651-672
pubmed: 27681694
Oncotarget. 2016 Jan 19;7(3):2343-53
pubmed: 26497678
Trends Biochem Sci. 2016 Mar;41(3):211-218
pubmed: 26778478
Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C823-C834
pubmed: 35876286
Stem Cells. 2011 Jan;29(1):32-45
pubmed: 21280157
Gene. 2016 Apr 1;579(2):162-71
pubmed: 26743125
J Exp Clin Cancer Res. 2019 May 23;38(1):218
pubmed: 31122265
J Exp Med. 2008 Sep 29;205(10):2409-17
pubmed: 18809715
Sci Rep. 2020 May 20;10(1):8341
pubmed: 32433524
Oncotarget. 2015 Oct 13;6(31):31119-33
pubmed: 26439801
Cancer Res. 2005 Nov 15;65(22):10441-9
pubmed: 16288035
Mol Med. 2004 Jul-Dec;10(7-12):65-71
pubmed: 16307172
Mol Cancer Ther. 2020 May;19(5):1134-1147
pubmed: 32127468
Medicine (Baltimore). 2016 Dec;95(49):e5602
pubmed: 27930583
J Pediatr Endocrinol Metab. 2011;24(5-6):385-7
pubmed: 21823542
Nutr Cancer. 1997;27(3):316-20
pubmed: 9101563
Asia Pac J Clin Oncol. 2017 Aug;13(4):329-336
pubmed: 27869361
Crit Care. 2009;13(1):R18
pubmed: 19216780
Biomed Pharmacother. 2018 Nov;107:306-328
pubmed: 30098549
Crit Care Clin. 2001 Jan;17(1):107-24
pubmed: 11219223
J Exp Clin Cancer Res. 2019 Jul 23;38(1):327
pubmed: 31337431
Anticancer Res. 2015 Jun;35(6):3147-54
pubmed: 26026074
Mol Cancer Res. 2013 Jul;11(7):736-47
pubmed: 23538858
Cancer Epidemiol Biomarkers Prev. 2021 Feb;30(2):335-343
pubmed: 33219162
Eur J Prev Cardiol. 2019 Dec;26(2_suppl):33-46
pubmed: 31766917
Biomed Pharmacother. 2022 Feb;146:112526
pubmed: 34906774
Cureus. 2020 May 7;12(5):e8010
pubmed: 32528752
Mol Med Rep. 2015 Jul;12(1):843-50
pubmed: 25815791
Science. 2001 Aug 31;293(5535):1673-7
pubmed: 11533494
Epigenetics Chromatin. 2019 Jul 17;12(1):44
pubmed: 31315653
Mol Ther Nucleic Acids. 2018 Sep 7;12:769-786
pubmed: 30141410
Oncol Res Treat. 2016;39(10):622-628
pubmed: 27710974
FASEB J. 2003 May;17(8):890-2
pubmed: 12626430
Cell Rep. 2019 Mar 12;26(11):3061-3075.e6
pubmed: 30865894
Clinics (Sao Paulo). 2011;66(1):77-82
pubmed: 21437440
Cell Oncol (Dordr). 2016 Aug;39(4):365-78
pubmed: 27106722
PLoS One. 2011;6(11):e27074
pubmed: 22087246
J Exp Clin Cancer Res. 2020 Jan 13;39(1):11
pubmed: 31931851
Molecules. 2020 Oct 20;25(20):
pubmed: 33092283
Cancer Res. 1992 Jul 15;52(14):3924-30
pubmed: 1617668
Endocrinology. 2018 Nov 1;159(11):3801-3812
pubmed: 30215698
Front Endocrinol (Lausanne). 2020 Jun 09;11:365
pubmed: 32582032
Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8150-4
pubmed: 1518840
J Clin Invest. 2006 Jul;116(7):1793-801
pubmed: 16823477
Nutr Cancer. 2020;72(5):734-746
pubmed: 31437005
Oncol Rep. 2018 Oct;40(4):1875-1884
pubmed: 30015982
Breast Cancer (Dove Med Press). 2017 Jun 13;9:429-436
pubmed: 28670141
Cancer Res. 2010 Jan 15;70(2):741-51
pubmed: 20068149
JAMA. 2019 Jan 22;321(3):288-300
pubmed: 30667505
J Zhejiang Univ Sci B. 2019 May;20(5):381-390
pubmed: 31090264
Breast Cancer Res. 2011 Aug 12;13(4):215
pubmed: 21884641
Diabetes Care. 2018 Apr;41(4):755-761
pubmed: 29351960
Cell Rep. 2022 Oct 25;41(4):111552
pubmed: 36288713
Arch Gynecol Obstet. 2011 Nov;284(5):1271-6
pubmed: 21249376
Indian J Med Paediatr Oncol. 2017 Oct-Dec;38(4):434-439
pubmed: 29333008
Cancers (Basel). 2021 Jan 19;13(2):
pubmed: 33478031
J Genet Genomics. 2012 Aug 20;39(8):369-74
pubmed: 22884093
Cancer Res. 1972 Feb;32(2):233-8
pubmed: 5058184
PLoS One. 2018 Oct 16;13(10):e0204269
pubmed: 30325922
Dis Colon Rectum. 2007 Aug;50(8):1230-40
pubmed: 17587138
Int J Cancer. 2017 Jul 1;141(1):102-111
pubmed: 28390156
Cancer Res. 2010 Jul 1;70(13):5337-47
pubmed: 20551060
Int J Mol Sci. 2021 Jul 21;22(15):
pubmed: 34360563
Mol Oncol. 2015 Jan;9(1):17-31
pubmed: 25106087
Cancers (Basel). 2010 Apr 28;2(2):721-39
pubmed: 24281091
Mol Med Rep. 2013 Feb;7(2):591-7
pubmed: 23151810
Kidney Int. 2011 Nov;80(9):926-937
pubmed: 21716257
Curr Diab Rep. 2013 Apr;13(2):213-22
pubmed: 23271574
Diabetes. 2010 Jan;59(1):249-55
pubmed: 19833897
Front Endocrinol (Lausanne). 2018 Jun 05;9:284
pubmed: 29915558
Biomed Res Int. 2018 Feb 8;2018:6565393
pubmed: 29581982
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Front Cell Dev Biol. 2021 Dec 15;9:803198
pubmed: 34977043
Mol Endocrinol. 1988 Jun;2(6):543-55
pubmed: 3047554
Biomed Rep. 2017 Aug;7(2):183-187
pubmed: 28781778
Tumour Biol. 2016 Nov;37(11):15065-15077
pubmed: 27658777
Breast Cancer Res. 2009;11(6):213
pubmed: 19909494
J Mol Endocrinol. 2013 Jun 29;51(1):119-29
pubmed: 23690508
Arch Biochem Biophys. 2020 Mar 15;681:108256
pubmed: 31923393
Indian J Med Res. 2017 Nov;146(5):553-556
pubmed: 29512595
BMC Genomics. 2020 Jul 18;21(1):491
pubmed: 32682390
Oncotarget. 2017 Apr 4;8(14):22325-22343
pubmed: 28423611