Beta-Lactam Antibiotics Can Be Measured in the Exhaled Breath Condensate in Mechanically Ventilated Patients: A Pilot Study.
HMEF
antibiotics
exhaled breath condensate
heat and moisture exchange filter
mechanical ventilation
pneumonia
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
17 Jul 2023
17 Jul 2023
Historique:
received:
28
06
2023
accepted:
12
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Different techniques have been proposed to measure antibiotic levels within the lung parenchyma; however, their use is limited because they are invasive and associated with adverse effects. We explore whether beta-lactam antibiotics could be measured in exhaled breath condensate collected from heat and moisture exchange filters (HMEFs) and correlated with the concentration of antibiotics measured from bronchoalveolar lavage (BAL). We designed an observational study in patients undergoing mechanical ventilation, which required a BAL to confirm or discard the diagnosis of pneumonia. We measured and correlated the concentration of beta-lactam antibiotics in plasma, epithelial lining fluid (ELF), and exhaled breath condensate collected from HMEFs. We studied 12 patients, and we detected the presence of antibiotics in plasma, ELF, and HMEFs from every patient studied. The concentrations of antibiotics were very heterogeneous over the population studied. The mean antibiotic concentration was 293.5 (715) ng/mL in plasma, 12.3 (31) ng/mL in ELF, and 0.5 (0.9) ng/mL in HMEF. We found no significant correlation between the concentration of antibiotics in plasma and ELF (R
Identifiants
pubmed: 37511759
pii: jpm13071146
doi: 10.3390/jpm13071146
pmc: PMC10381781
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Appl Physiol (1985). 2017 Jul 1;123(1):136-146
pubmed: 28280105
J Diabetes Sci Technol. 2023 Jul 4;:19322968231179728
pubmed: 37401788
JAMA. 1997 Dec 17;278(23):2080-4
pubmed: 9403422
Ann Transl Med. 2021 Apr;9(7):583
pubmed: 33987281
Antimicrob Agents Chemother. 2016 Sep 23;60(10):5849-57
pubmed: 27431215
J Pharmacokinet Pharmacodyn. 2001 Oct;28(5):481-504
pubmed: 11768292
Gastroenterol Hepatol. 2013 Aug-Sep;36(7):443-9
pubmed: 23849764
J Crit Care. 2019 Jun;51:46-50
pubmed: 30745285
J Thorac Oncol. 2018 Aug;13(8):1213-1216
pubmed: 29751135
Adv Clin Chem. 2019;88:121-149
pubmed: 30612604
Sci Total Environ. 2019 Feb 15;651(Pt 1):1605-1612
pubmed: 30360286
J Heart Lung Transplant. 2001 Feb;20(2):184
pubmed: 11250308
Best Pract Res Clin Anaesthesiol. 2005 Sep;19(3):331-48
pubmed: 16013685
Am J Respir Crit Care Med. 2019 Mar 1;199(5):603-612
pubmed: 30216736
Am J Respir Crit Care Med. 2018 Apr 15;197(8):1027-1035
pubmed: 29253353
Am J Respir Cell Mol Biol. 2023 Jul;69(1):113-115
pubmed: 37387613
Clin Ther. 2016 Sep;38(9):1930-47
pubmed: 27449411
Am J Respir Crit Care Med. 2001 Jun;163(7):1730-54
pubmed: 11401897
AJR Am J Roentgenol. 2010 Aug;195(2):292-300
pubmed: 20651183
J Pharmacokinet Pharmacodyn. 2008 Feb;35(1):101-16
pubmed: 17963024
Sensors (Basel). 2018 May 04;18(5):
pubmed: 29734646
Anesthesiology. 2016 Nov;125(5):992-1004
pubmed: 27611185
Nat Rev Dis Primers. 2021 Apr 8;7(1):25
pubmed: 33833230
Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0156421
pubmed: 34570645
J Pharm Biomed Anal. 2021 Mar 20;196:113906
pubmed: 33486448
Int J Mol Sci. 2022 Aug 29;23(17):
pubmed: 36077213
Ann Transl Med. 2019 Feb;7(3):49
pubmed: 30906753
Biomed Res Int. 2016;2016:4307987
pubmed: 26904674
Adv Mater. 2022 Jan;34(2):e2104555
pubmed: 34545651
Intensive Care Med. 2008 Oct;34(10):1827-34
pubmed: 18478200
Crit Care. 2019 Mar 29;23(1):104
pubmed: 30925922
Respir Care Clin N Am. 2006 Jun;12(2):253-61
pubmed: 16828693
J Clin Med. 2021 Jun 18;10(12):
pubmed: 34207327
J Pharmacokinet Pharmacodyn. 2011 Aug;38(4):423-32
pubmed: 21626437
Clin Pharmacokinet. 2011 Oct;50(10):637-64
pubmed: 21895037
J Breath Res. 2019 Aug 20;13(4):044002
pubmed: 31282387
Pharmacol Res Perspect. 2015 Mar;3(2):e00131
pubmed: 26038706
Dis Markers. 2020 Jan 11;2020:2696317
pubmed: 31998415
Crit Care. 2018 Sep 24;22(1):233
pubmed: 30244674
Br J Anaesth. 2009 May;102(5):608-13
pubmed: 19336539
J Pharmacol Pharmacother. 2016 Jan-Mar;7(1):15-21
pubmed: 27127389
J Chemother. 1996 Feb;8 Suppl 2:71-82
pubmed: 8738849
Antimicrob Agents Chemother. 2008 Jan;52(1):24-36
pubmed: 17846133
J Antimicrob Chemother. 2016 Jan;71(1):196-207
pubmed: 26433783