Matrix Metalloproteinases and Heart Transplantation-A Pathophysiological and Clinical View.


Journal

Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208

Informations de publication

Date de publication:
13 Jul 2023
Historique:
received: 05 06 2023
revised: 05 07 2023
accepted: 12 07 2023
medline: 31 7 2023
pubmed: 29 7 2023
entrez: 29 7 2023
Statut: epublish

Résumé

Heart transplantation is undergoing a continuous development, with rates of success increasing substantially due to advances in immunosuppressive therapy and surgical techniques. The most worrying complication occurring after cardiac transplantation is graft rejection, a phenomenon that is much affected by matrix metalloproteinases (MMPs), with the role of these proteases in the cardiac remodeling process being well established in the literature. A detailed investigation of the association between MMPs and cardiac rejection is necessary for the future development of more targeted therapies in transplanted patients, and to discover prognostic serum and immunohistochemical markers that will lead to more organized therapeutic management in these patients. The aim of this review is therefore to highlight the main MMPs relevant to cardiovascular pathology, with particular emphasis on those involved in complications related to heart transplantation, including cardiac graft rejection.

Identifiants

pubmed: 37512106
pii: medicina59071295
doi: 10.3390/medicina59071295
pmc: PMC10383867
pii:
doi:

Substances chimiques

Matrix Metalloproteinases EC 3.4.24.-

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Gabriela Patrichi (G)

Department of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania.

Andrei Patrichi (A)

Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania.

Catalin-Bogdan Satala (CB)

Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania.
Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.

Anca Ileana Sin (AI)

Department of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania.

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Classifications MeSH