Pilot Study on the Use of Untargeted Metabolomic Fingerprinting of Liquid-Cytology Fluids as a Diagnostic Tool of Malignancy for Thyroid Nodules.
deep learning
diagnostic biomarkers
fine-needle aspiration cytology
indeterminate thyroid nodules
machine learning
metabolomics
thyroid cancer
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
23 Jun 2023
23 Jun 2023
Historique:
received:
14
05
2023
revised:
16
06
2023
accepted:
21
06
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Although it is the gold standard for assessing the malignancy of thyroid nodules (TNs) preoperatively, the cytological analysis of fine-needle aspiration cytology (FNAC) samples results in 20-30% of cases in indeterminate lesions (ITNs). As two-thirds of these lesions will appear benign after diagnostic surgery, improved preoperative diagnostic methods need to be developed. In this pilot study, we evaluate if the metabolomic profiles of liquid-based (CytoRich
Identifiants
pubmed: 37512489
pii: metabo13070782
doi: 10.3390/metabo13070782
pmc: PMC10384948
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
JAMA Oncol. 2019 Feb 1;5(2):204-212
pubmed: 30419129
Lancet Diabetes Endocrinol. 2021 Apr;9(4):193-194
pubmed: 33662332
Metabolomics. 2018 Oct 10;14(10):141
pubmed: 30830426
Thyroid. 2019 Sep;29(9):1237-1243
pubmed: 31407625
Nucleic Acids Res. 2021 Jul 2;49(W1):W388-W396
pubmed: 34019663
Front Endocrinol (Lausanne). 2020 Oct 09;11:590128
pubmed: 33162941
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
Trends Biotechnol. 1998 Sep;16(9):373-8
pubmed: 9744112
Curr Opin Biotechnol. 2002 Apr;13(2):156-60
pubmed: 11950569
J Proteome Res. 2015 Aug 7;14(8):3315-21
pubmed: 26130307
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
EBioMedicine. 2017 Apr;18:11-12
pubmed: 28363611
Int J Endocrinol. 2015;2015:258763
pubmed: 25972898
JAMA Otolaryngol Head Neck Surg. 2022 Jun 1;148(6):531-539
pubmed: 35511129
Drug Discov Ther. 2020 Sep 8;14(4):187-196
pubmed: 32848112
Cell Metab. 2008 Jan;7(1):11-20
pubmed: 18177721
J Am Soc Cytopathol. 2022 Mar-Apr;11(2):74-78
pubmed: 34366280
Theranostics. 2021 Jan 1;11(3):1310-1325
pubmed: 33391536
Talanta. 2021 Dec 1;235:122729
pubmed: 34517597
Curr Opin Genet Dev. 2008 Feb;18(1):54-61
pubmed: 18387799
Thyroid. 2019 Aug;29(8):1115-1124
pubmed: 31154940
J Proteome Res. 2012 Jun 1;11(6):3317-25
pubmed: 22509853
Genes (Basel). 2019 Sep 23;10(10):
pubmed: 31547603
Endocr Pract. 2016 May;22(5):622-39
pubmed: 27167915
Int J Cancer. 2019 Jun 1;144(11):2728-2745
pubmed: 30565661
Thyroid. 2017 Nov;27(11):1341-1346
pubmed: 29091573
Eur Thyroid J. 2017 Sep;6(5):225-237
pubmed: 29167761
Surgery. 2012 Dec;152(6):1118-24
pubmed: 23158182
Biomarkers. 2017 Nov;22(7):595-603
pubmed: 27805426
Sci Rep. 2016 Jul 21;6:30075
pubmed: 27440433
Thyroid. 2016 Jan;26(1):1-133
pubmed: 26462967
Lancet. 2016 Dec 3;388(10061):2783-2795
pubmed: 27240885
PLoS One. 2013 Dec 23;8(12):e84637
pubmed: 24376829
Endocrinol Metab Clin North Am. 2007 Sep;36(3):707-35, vi
pubmed: 17673125
Int J Mol Med. 2015 Dec;36(6):1607-14
pubmed: 26459747
BMC Bioinformatics. 2010 Jul 23;11:395
pubmed: 20650010
BMC Bioinformatics. 2022 Sep 1;23(1):361
pubmed: 36050631
Pediatr Surg Int. 2020 Feb;36(2):145-153
pubmed: 31576470