Crosstalk between Breast Milk N-Acetylneuraminic Acid and Infant Growth in a Gut Microbiota-Dependent Manner.
N-acetylneuraminic acid
bile acids
breast milk
germ-free mice
gut microbiota
infant growth
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
13 Jul 2023
13 Jul 2023
Historique:
received:
14
06
2023
revised:
05
07
2023
accepted:
12
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
The healthy growth of infants during early life is associated with lifelong consequences. Breastfeeding has positive impacts on reducing obesity risk, which is likely due to the varied components of breast milk, such as N-acetylneuraminic acid (Neu5Ac). However, the effect of breast milk Neu5Ac on infant growth has not been well studied. In this study, targeted metabolomic and metagenomic analyses were performed to illustrate the association between breast milk Neu5Ac and infant growth. Results demonstrated that Neu5Ac was significantly abundant in breast milk from infants with low obesity risk in two independent Chinese cohorts. Neu5Ac from breast milk altered infant gut microbiota and bile acid metabolism, resulting in a distinct fecal bile acid profile in the high-Neu5Ac group, which was characterized by reduced levels of primary bile acids and elevated levels of secondary bile acids. Taurodeoxycholic acid 3-sulfate and taurochenodeoxycholic acid 3-sulfate were correlated with high breast milk Neu5Ac and low obesity risk in infants, and their associations with healthy growth were reproduced in mice colonized with infant-derived microbiota.
Identifiants
pubmed: 37512553
pii: metabo13070846
doi: 10.3390/metabo13070846
pmc: PMC10385641
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the Youth Science and Technology Star Project Support Program from the Scientific and Technological Office of Dalian
ID : No. 2020RQ067
Organisme : the Youth Innovation Promotion Association of Chinese Academy of Sciences
ID : No. 2021186
Organisme : the Innovation Program of Science and Research from Dalian Institute of Chemical Physics, Chinese Academy of Sciences
ID : DICP I202019
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