Anxiety-like Behavior in Female Sprague Dawley Rats Associated with Cecal Clostridiales.
Clostridiales
anxiety
cytokines
microbiome
microbiome–gut–brain axis
stress
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
07 Jul 2023
07 Jul 2023
Historique:
received:
04
05
2023
revised:
19
06
2023
accepted:
03
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
The relationship between the microbiota profile and exposure to stress is not well understood. Therefore, we used a rat model of unpredictable chronic mild stress (UCMS) to investigate this relationship. Depressive-like behaviors were measured in Female Sprague Dawley rats using the sucrose preference test and the Porsolt swim test. Anxiety-like behaviors were measured with the light-dark box test. Fecal corticosterone, cecal microbiota (composition and organic acids), plasma gut permeability (lipopolysaccharide-binding protein, LBP) and plasma inflammation (12 cytokines) markers were measured. Atypical behaviors were observed in female rats following UCMS, but no depressive-like behaviors were observed. Circulating concentrations of cytokines granulocyte-macrophage colony-stimulating factor and cytokine-induced neutrophil chemoattractant 1 were higher in UCMS-exposed female rats; plasma LBP and cecal organic acid levels remained unchanged. Our results reflect a resilient and adaptive phenotype for female SD rats. The relative abundance of taxa from the Clostridiales order and
Identifiants
pubmed: 37512945
pii: microorganisms11071773
doi: 10.3390/microorganisms11071773
pmc: PMC10386170
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Riddet Institute
ID : n/a
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