Interaction of Doxorubicin Embedded into Phospholipid Nanoparticles and Targeted Peptide-Modified Phospholipid Nanoparticles with DNA.
DNA
NGR peptide
doxorubicin
drug–DNA interaction
electrochemical monitoring
nanoliposomes
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 Jul 2023
10 Jul 2023
Historique:
received:
24
05
2023
revised:
22
06
2023
accepted:
05
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
The interactions of dsDNA with new targeted drug delivery derivatives of doxorubicin (DOX), such as DOX embedded into phospholipid nanoparticles (NPhs) and DOX with the NGR targeted peptide-modified NPhs were studied electrochemically by differential pulse voltammetry technique. Screen-printed electrodes (SPEs), modified with stable fine dispersions of carbon nanotubes (CNTs), were used for quantitative electrochemical investigations of direct electrochemical oxidation of guanine, adenine, and thymine heterocyclic bases of dsDNA, and their changes in the presence of DOX nanoderivatives. Analysing the shifts of peak potentials of nucleobases in the presence of drug, we have shown that the doxorubicin with NGR targeted peptide changed the mode of interaction in DNA-drug complexes from intercalative to electrostatic. Binding constants (
Identifiants
pubmed: 37513191
pii: molecules28145317
doi: 10.3390/molecules28145317
pmc: PMC10385298
pii:
doi:
Substances chimiques
Phospholipids
0
Nanotubes, Carbon
0
Thymine
QR26YLT7LT
Doxorubicin
80168379AG
Peptides
0
DNA
9007-49-2
Adenine
JAC85A2161
Guanine
5Z93L87A1R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education Russian Federation
ID : No. 75-15-2020-913
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