Matrix Metalloproteinases Inhibitors in Cancer Treatment: An Updated Review (2013-2023).
anticancer activity
extra-cellular matrix remodeling
inhibitors
matrix metalloproteinases (MMPs)
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Jul 2023
21 Jul 2023
Historique:
received:
22
05
2023
revised:
09
07
2023
accepted:
18
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be categorized into six groups based on their substrate specificity and structural differences: collagenases, gelatinases, stromelysins, matrilysins, metalloelastase, and membrane-type MMPs. MMPs have been linked to a wide variety of biological processes, such as cell transformation and carcinogenesis. Over time, MMPs have been evaluated for their role in cancer progression, migration, and metastasis. Accordingly, various MMPs have become attractive therapeutic targets for anticancer drug development. The first generations of broad-spectrum MMP inhibitors displayed effective inhibitory activities but failed in clinical trials due to poor selectivity. Thanks to the evolution of X-ray crystallography, NMR analysis, and homology modeling studies, it has been possible to characterize the active sites of various MMPs and, consequently, to develop more selective, second-generation MMP inhibitors. In this review, we summarize the computational and synthesis approaches used in the development of MMP inhibitors and their evaluation as potential anticancer agents.
Identifiants
pubmed: 37513440
pii: molecules28145567
doi: 10.3390/molecules28145567
pmc: PMC10384300
pii:
doi:
Substances chimiques
Matrix Metalloproteinase Inhibitors
0
Matrix Metalloproteinases
EC 3.4.24.-
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
SAR QSAR Environ Res. 2019 Apr;30(4):247-263
pubmed: 31012354
ACS Med Chem Lett. 2010 Oct 20;2(1):28-33
pubmed: 24900251
Mol Divers. 2023 Jun;27(3):1053-1066
pubmed: 35773549
Exp Biol Med (Maywood). 2006 Jan;231(1):20-7
pubmed: 16380641
Exp Mol Pathol. 2011 Feb;90(1):91-6
pubmed: 20969861
Clin Cancer Res. 2005 Feb 1;11(3):1086-92
pubmed: 15709175
Gene. 2022 May 5;821:146319
pubmed: 35182673
J Biol Chem. 2011 Sep 23;286(38):33167-77
pubmed: 21795678
Biochimie. 2005 Mar-Apr;87(3-4):385-92
pubmed: 15781326
Cancer Lett. 2002 Mar 8;177(1):95-100
pubmed: 11809536
Adv Clin Chem. 2015;72:107-70
pubmed: 26471082
PLoS One. 2015 Aug 10;10(8):e0135265
pubmed: 26258591
Biochem Biophys Res Commun. 2002 Feb 15;291(1):130-8
pubmed: 11829472
NanoImpact. 2021 Jan;21:100293
pubmed: 35559782
Eur J Med Chem. 2021 Mar 5;213:113044
pubmed: 33279289
Int J Mol Sci. 2021 Aug 20;22(16):
pubmed: 34445715
Cell. 2009 Apr 17;137(2):332-43
pubmed: 19379698
J Med Chem. 2009 Oct 22;52(20):6347-61
pubmed: 19775099
Cells. 2019 Aug 28;8(9):
pubmed: 31466240
Carcinogenesis. 2006 May;27(5):1113-20
pubmed: 16474169
Semin Cancer Biol. 2019 Jun;56:100-115
pubmed: 29155240
Int J Clin Exp Med. 2015 Feb 15;8(2):2261-6
pubmed: 25932160
J Med Chem. 2014 Dec 26;57(24):10205-19
pubmed: 25265401
Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12530-5
pubmed: 19617536
Nat Rev Cancer. 2006 Mar;6(3):227-39
pubmed: 16498445
Cardiovasc Ther. 2012 Feb;30(1):31-41
pubmed: 20645986
FEBS J. 2011 Jan;278(1):28-45
pubmed: 21087458
Cardiovasc Res. 2006 Feb 15;69(3):562-73
pubmed: 16405877
Biochem Biophys Res Commun. 2005 Aug 5;333(3):1011-6
pubmed: 15964556
Int J Clin Exp Med. 2015 Jul 15;8(7):10845-54
pubmed: 26379878
Mol Cancer Ther. 2018 Jun;17(6):1147-1155
pubmed: 29735645
Chem Biol Drug Des. 2015 Dec;86(6):1405-10
pubmed: 26061284
Amino Acids. 2011 Jul;41(2):271-90
pubmed: 20640864
Mol Cell Biol. 2008 Apr;28(7):2391-413
pubmed: 18172013
Matrix Biol. 2007 Oct;26(8):587-96
pubmed: 17669641
PLoS One. 2009 Aug 10;4(8):e6565
pubmed: 19668337
J Med Chem. 2020 Dec 10;63(23):15037-15049
pubmed: 33206510
Matrix Biol. 2019 Jan;75-76:271-285
pubmed: 29253518
Prog Mol Biol Transl Sci. 2017;147:1-73
pubmed: 28413025
Curr Med Chem. 2001 Mar;8(4):425-74
pubmed: 11172697
Sci Rep. 2015 May 08;5:9504
pubmed: 25955565
Expert Opin Ther Targets. 2003 Jun;7(3):385-97
pubmed: 12783574
Neoplasia. 2020 Oct;22(10):511-521
pubmed: 32896761
Cancer Res. 2012 May 1;72(9):2339-49
pubmed: 22406620
Adv Drug Deliv Rev. 2016 Feb 1;97:4-27
pubmed: 26562801
Cell Death Dis. 2014 Dec 11;5:e1564
pubmed: 25501825
Cancer Genet. 2023 Apr;272-273:9-15
pubmed: 36640492
Biochem J. 2017 Feb 20;474(5):647-665
pubmed: 28008134
J Mol Biol. 2004 Aug 20;341(4):1063-76
pubmed: 15289103
Cancer. 1998 Apr 1;82(7):1359-66
pubmed: 9529029
Oncogene. 2004 Jan 22;23(3):845-51
pubmed: 14647437
Oncologist. 2001;6(5):415-27
pubmed: 11675519
J Clin Med. 2021 Apr 01;10(7):
pubmed: 33916127
Mol Inform. 2014 Sep;33(9):573-87
pubmed: 27486078
Expert Opin Ther Pat. 2021 Jun;31(6):509-523
pubmed: 33487088
Carcinogenesis. 2009 May;30(5):793-8
pubmed: 19321798
Med Sci Monit. 2009 Feb;15(2):RA32-40
pubmed: 19182722
FEBS J. 2021 Dec;288(24):6850-6912
pubmed: 33605520
J Med Chem. 2009 Apr 9;52(7):1799-802
pubmed: 19278250
Rheumatol Int. 2013 Feb;33(2):435-9
pubmed: 22457004
J Ovarian Res. 2021 Aug 3;14(1):101
pubmed: 34344453
Thromb Haemost. 2013 Nov;110(5):903-9
pubmed: 23864155
Am J Pathol. 2005 May;166(5):1555-63
pubmed: 15855654
Curr Med Chem. 2010;17(36):4448-61
pubmed: 21062258
Bioorg Med Chem. 2020 Feb 1;28(3):115257
pubmed: 31874775
Postepy Biochem. 2007;53(1):37-45
pubmed: 17718386
Science. 1999 Jun 4;284(5420):1667-70
pubmed: 10356396
Nat Rev Mol Cell Biol. 2014 Dec;15(12):786-801
pubmed: 25415508
Drug Discov Today. 2020 Jan;25(1):38-57
pubmed: 31513929
BMC Cancer. 2022 May 11;22(1):530
pubmed: 35545767
Int J Mol Sci. 2022 Sep 11;23(18):
pubmed: 36142454
Genomics. 1995 Jul 20;28(2):360-1
pubmed: 8530054
J Pathol. 2004 Jan;202(1):14-22
pubmed: 14694517
Molecules. 2017 Sep 14;22(9):
pubmed: 32961647
Wound Repair Regen. 2019 Jul;27(4):309-323
pubmed: 30761682
Eur J Med Chem. 2019 Nov 1;181:111563
pubmed: 31415980
Matrix Biol. 2015 May-Jul;44-46:207-23
pubmed: 25794647
BMC Cancer. 2011 Aug 11;11:348
pubmed: 21835023
Biochemistry. 2009 Nov 24;48(46):10830-45
pubmed: 19817485
Cancer Biol Ther. 2013 Sep;14(9):796-805
pubmed: 23917402
Oncol Rep. 2001 Mar-Apr;8(2):401-3
pubmed: 11182063
Eur J Med Chem. 2017 Sep 29;138:979-992
pubmed: 28756264
Lung Cancer. 2023 Jan;175:125-130
pubmed: 36508772
J Biol Chem. 2003 Dec 19;278(51):51646-53
pubmed: 14532275
Mol Divers. 2018 May;22(2):383-395
pubmed: 29423648
Eur J Med Chem. 2013 Apr;62:148-57
pubmed: 23353736
Toxicol Appl Pharmacol. 2021 Sep 1;426:115593
pubmed: 34038713
J Med Chem. 2020 Nov 12;63(21):12911-12920
pubmed: 33107733
Front Med (Lausanne). 2020 Dec 21;7:617261
pubmed: 33409288
J Int Med Res. 2020 Jan;48(1):300060519825983
pubmed: 31099295
Circ Res. 2002 May 31;90(10):1093-9
pubmed: 12039799
Biomed Res Int. 2014;2014:908636
pubmed: 25050378
Mol Med. 2016 Oct;22:487-496
pubmed: 27385318
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15805-10
pubmed: 17890317
Pharmaceuticals (Basel). 2019 May 20;12(2):
pubmed: 31137480
Bioorg Chem. 2022 Jul;124:105816
pubmed: 35489270
Ann Surg. 2002 Apr;235(4):519-27
pubmed: 11923608
BMC Res Notes. 2015 Jul 29;8:322
pubmed: 26219353
Int J Oncol. 2000 Oct;17(4):673-81
pubmed: 10995877
Rom J Morphol Embryol. 2007;48(4):323-34
pubmed: 18060181
BMC Cancer. 2009 Dec 04;9:422
pubmed: 19961596
Biomed Res Int. 2022 Apr 22;2022:2300979
pubmed: 35496040
Int J Cancer. 2000 Jan 1;85(1):14-20
pubmed: 10585576
Mol Cancer. 2017 Feb 28;16(1):49
pubmed: 28241871
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):1940-1951
pubmed: 28456643
Sci Rep. 2021 Mar 4;11(1):5224
pubmed: 33664351
Acta Oncol. 2010;49(1):85-90
pubmed: 19929564
Int J Mol Sci. 2021 Sep 25;22(19):
pubmed: 34638665
Future Med Chem. 2021 Nov;13(22):1987-2013
pubmed: 34634916
ACS Med Chem Lett. 2013 May 14;4(6):565-9
pubmed: 24900710
Int J Mol Sci. 2016 Jun 02;17(6):
pubmed: 27271600
Bioorg Med Chem Lett. 2015 Oct 15;25(20):4664-71
pubmed: 26346367
Eur J Cancer. 2011 Oct;47(15):2299-305
pubmed: 21683576
Breast Cancer Res. 2000;2(4):252-7
pubmed: 11250717
Cell. 1998 Feb 6;92(3):391-400
pubmed: 9476898
Acta Pharmacol Sin. 2018 Jul;39(7):1068-1072
pubmed: 29645001
Int J Mol Sci. 2016 Oct 22;17(10):
pubmed: 27782083
Biochem Soc Trans. 2022 Apr 29;50(2):839-851
pubmed: 35343563
BMC Cancer. 2016 Jul 18;16:494
pubmed: 27431388
Cancer Manag Res. 2020 Oct 30;12:10949-10964
pubmed: 33154674
Int J Clin Exp Med. 2015 Jun 15;8(6):8948-57
pubmed: 26309547
Circ Res. 2003 May 2;92(8):827-39
pubmed: 12730128
Proc Natl Acad Sci U S A. 1962 Jun 15;48:1014-22
pubmed: 13902219
Mol Med Rep. 2012 Jun;5(6):1438-42
pubmed: 22469989
Bioorg Chem. 2020 Jan;94:103365
pubmed: 31676116
Phytother Res. 2016 Jan;30(1):112-9
pubmed: 26556014
J Enzyme Inhib Med Chem. 2016;31(sup1):177-183
pubmed: 27028474
Auris Nasus Larynx. 2008 Sep;35(3):381-9
pubmed: 18276095
J Cutan Pathol. 2020 Feb;47(2):139-145
pubmed: 31677173
J Med Chem. 2015 Sep 24;58(18):7224-40
pubmed: 26263024
Biochim Biophys Acta. 2015 Dec;1852(12):2593-602
pubmed: 26343184
Breast Cancer Res. 2005;7(4):R506-12
pubmed: 15987457
Neurobiol Dis. 2015 Oct;82:141-151
pubmed: 26079709
Prog Mol Biol Transl Sci. 2017;148:327-338
pubmed: 28662826
Front Physiol. 2021 Nov 29;12:704401
pubmed: 34912233
PLoS One. 2012;7(8):e44066
pubmed: 22952876
Chemistry. 2019 Jun 18;25(34):7960-7980
pubmed: 30720221
Biochem Res Int. 2011;2011:191670
pubmed: 21152183
Cancer Lett. 2014 Mar 28;344(2):195-203
pubmed: 24211326
Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G78-86
pubmed: 25977510
Head Neck. 2006 Jul;28(7):639-48
pubmed: 16470875
Onkologie. 2012;35(11):651-6
pubmed: 23147541
J Med Chem. 2019 Jul 11;62(13):5944-5978
pubmed: 30682248
Tumour Biol. 2013 Aug;34(4):2041-51
pubmed: 23681802
Stroke. 2015 Dec;46(12):3523-31
pubmed: 26534974
J Med Chem. 2018 May 10;61(9):4115-4134
pubmed: 29660282
Am J Pathol. 2006 Oct;169(4):1390-401
pubmed: 17003494
Enzyme Protein. 1996;49(1-3):7-19
pubmed: 8796994
Oncol Rep. 2020 Apr;43(4):1103-1112
pubmed: 32323782
Nat Med. 2014 May;20(5):493-502
pubmed: 24784232
Int J Mol Sci. 2020 Dec 20;21(24):
pubmed: 33419373
J Biomed Sci. 2011 Nov 25;18:86
pubmed: 22114952
Sci Rep. 2022 Dec 3;12(1):20915
pubmed: 36463250
Clin Biochem. 2021 Jun;92:9-18
pubmed: 33713636
Cells. 2020 Feb 17;9(2):
pubmed: 32079295
Int J Colorectal Dis. 2013 Aug;28(8):1151-9
pubmed: 23619615
Expert Opin Drug Discov. 2018 Jan;13(1):75-87
pubmed: 29088927
Anticancer Res. 2020 Jul;40(7):3619-3631
pubmed: 32620601
Am J Pathol. 2004 Apr;164(4):1131-9
pubmed: 15039201
Expert Opin Ther Targets. 2013 Feb;17(2):203-16
pubmed: 23252422
J Biol Chem. 2013 Sep 6;288(36):25964-25975
pubmed: 23902766
Cancer. 2001 Apr 1;91(7):1277-83
pubmed: 11283927
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):2043-2055
pubmed: 28526562
Pharmacol Res. 2016 Sep;111:17-22
pubmed: 27221755
Front Physiol. 2021 Jul 02;12:663978
pubmed: 34276395
Bioorg Med Chem Lett. 2012 Jan 1;22(1):138-43
pubmed: 22153340
J Chem Inf Model. 2006 Sep-Oct;46(5):2104-9
pubmed: 16995741
Bioorg Med Chem. 2019 Jan 1;27(1):196-207
pubmed: 30522899
Bioorg Med Chem. 2023 May 1;85:117289
pubmed: 37094433
Differentiation. 2002 Dec;70(9-10):561-73
pubmed: 12492497
Org Biomol Chem. 2015 Jan 21;13(3):793-806
pubmed: 25406681
J Pathol. 2003 Dec;201(4):528-34
pubmed: 14648655
Oncol Lett. 2019 Feb;17(2):1826-1832
pubmed: 30675244
Cancer Control. 2021 Jan-Dec;28:10732748211033743
pubmed: 34482737
Birth Defects Res C Embryo Today. 2006 Mar;78(1):1-10
pubmed: 16622845
Eur J Med Chem. 2021 Nov 5;223:113623
pubmed: 34157437
J Inorg Biochem. 2016 Dec;165:7-17
pubmed: 27755977
Anticancer Agents Med Chem. 2017;17(5):674-681
pubmed: 27491937
J Cell Physiol. 2008 Dec;217(3):643-51
pubmed: 18636552
Sci Rep. 2020 Sep 7;10(1):14710
pubmed: 32895466
Oncol Lett. 2018 Jul;16(1):475-482
pubmed: 29928435
J Med Chem. 2022 Aug 25;65(16):10709-10754
pubmed: 35969157
Crit Rev Oncol Hematol. 2019 May;137:57-83
pubmed: 31014516
Nat Rev Cancer. 2002 Sep;2(9):657-72
pubmed: 12209155
J Mol Biol. 2006 Sep 8;362(1):78-88
pubmed: 16890240
Adv Pharmacol. 2018;81:241-330
pubmed: 29310800
Int J Immunopathol Pharmacol. 2015 Mar;28(1):77-84
pubmed: 25816409
Blood. 2011 Apr 28;117(17):4476-89
pubmed: 21378275
Arthritis Res. 2002;4(3):157-64
pubmed: 12010565
ACS Med Chem Lett. 2017 May 01;8(6):654-659
pubmed: 28626528
J Cell Biochem. 2009 Dec 15;108(6):1233-43
pubmed: 19798678
Reproduction. 2015 Aug;150(2):R55-64
pubmed: 25918438
Front Oncol. 2021 Sep 17;11:717606
pubmed: 34604053
Am J Transl Res. 2022 Jul 15;14(7):4391-4405
pubmed: 35958464
J Trace Elem Med Biol. 2019 Dec;56:107-115
pubmed: 31442948
J Breast Cancer. 2020 Feb 18;23(1):1-9
pubmed: 32140265
Tumour Biol. 2011 Apr;32(2):259-64
pubmed: 21207220
Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3816-3821
pubmed: 30342958
J Med Chem. 2010 Sep 23;53(18):6653-80
pubmed: 20726512
ISRN Urol. 2012;2012:581539
pubmed: 22852097
Oncol Res. 2018 Jun 11;26(5):735-741
pubmed: 28800790
Anticancer Res. 2023 Jan;43(1):381-387
pubmed: 36585199
J Pathol. 2002 Oct;198(2):258-69
pubmed: 12237887
Dig Dis Sci. 2010 Nov;55(11):3138-46
pubmed: 20127415
Mol Neurobiol. 2018 Feb;55(2):1405-1409
pubmed: 28155200
Mol Diagn Ther. 2007;11(3):183-92
pubmed: 17570740
J Thromb Haemost. 2008 Mar;6(3):517-23
pubmed: 18088350
Br J Pharmacol. 2008 Jul;154(6):1206-15
pubmed: 18493250
FEBS J. 2021 Dec;288(24):7162-7182
pubmed: 33405316
Int J Gynecol Cancer. 2009 Jan;19(1):129-33
pubmed: 19258954
Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):101-17
pubmed: 15000152
Curr Opin Cell Biol. 2001 Oct;13(5):534-40
pubmed: 11544020
J Invest Dermatol. 2000 Jun;114(6):1113-9
pubmed: 10844553
Cells. 2020 Apr 26;9(5):
pubmed: 32357580
Med Chem. 2006 Sep;2(5):523-6
pubmed: 17017992
Biochim Biophys Acta. 2014 Oct;1840(10):3162-9
pubmed: 25046380
Curr Med Chem. 2005;12(3):339-55
pubmed: 15723623
J Stroke Cerebrovasc Dis. 2018 Jan;27(1):140-152
pubmed: 28958661