IgE Mediated Shellfish Allergy in Children-A Review.

allergen-specific immunotherapy crustaceans molluscs oral food challenge shellfish allergy tropomyosin

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
12 Jul 2023
Historique:
received: 26 06 2023
revised: 08 07 2023
accepted: 10 07 2023
medline: 31 7 2023
pubmed: 29 7 2023
entrez: 29 7 2023
Statut: epublish

Résumé

Shellfish is a leading cause of food allergy and anaphylaxis worldwide. Recent advances in molecular characterization have led to a better understanding of the allergen profile. High sequence homology between shellfish species and between shellfish and house dust mites leads to a high serological cross-reactivity, which does not accurately correlate with clinical cross-reactions. Clinical manifestations are immediate and the predominance of perioral symptoms is a typical feature of shellfish allergy. Diagnosis, as for other food allergies, is based on SPTs and specific IgE, while the gold standard is DBPCFC. Cross-reactivity between shellfish is common and therefore, it is mandatory to avoid all shellfish. New immunotherapeutic strategies based on hypoallergens and other innovative approaches represent the new frontiers for desensitization.

Identifiants

pubmed: 37513530
pii: nu15143112
doi: 10.3390/nu15143112
pmc: PMC10386692
pii:
doi:

Substances chimiques

Immunoglobulin E 37341-29-0
Allergens 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Arianna Giannetti (A)

Paediatrics Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Andrea Pession (A)

Paediatrics Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Irene Bettini (I)

Paediatrics Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Giampaolo Ricci (G)

Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.

Giuliana Giannì (G)

Clinica Pediatrica, Azienda Ospedaliero-Universitaria, Medicine and Surgery Department, Università di Parma, 43126 Parma, Italy.

Carlo Caffarelli (C)

Clinica Pediatrica, Azienda Ospedaliero-Universitaria, Medicine and Surgery Department, Università di Parma, 43126 Parma, Italy.

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