Mouse Models for Human Herpesviruses.
human herpesvirus
humanized models
interspecies models
mouse models
mouse orthologue viruses
review
xenografted mice
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
19 Jul 2023
19 Jul 2023
Historique:
received:
31
05
2023
revised:
13
07
2023
accepted:
15
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investigate the consequences of infections and identify novel treatment options, in vivo models are of particular relevance. The mouse has emerged as an economical small animal model to investigate herpesvirus infections. However, except for herpes simplex viruses (HSV-1, HSV-2), human herpesviruses cannot infect mice. Three natural herpesviruses have been identified in mice: mouse-derived cytomegalovirus (MCMV), mouse herpesvirus 68 (MHV-68), and mouse roseolovirus (MRV). These orthologues are broadly used to investigate herpesvirus infections within the natural host. In the last few decades, immunocompromised mouse models have been developed, allowing the functional engraftment of various human cells and tissues. These xenograft mice represent valuable model systems to investigate human-restricted viruses, making them particularly relevant for herpesvirus research. In this review, we describe the various mouse models used to study human herpesviruses, thereby highlighting their potential and limitations. Emphasis is laid on xenograft mouse models, covering the development and refinement of immune-compromised mice and their application in herpesvirus research.
Identifiants
pubmed: 37513800
pii: pathogens12070953
doi: 10.3390/pathogens12070953
pmc: PMC10384569
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Niedersachsen
ID : Niedersachsen Vorab
Organisme : Helmholtz Society
ID : ind
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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