Curcumin Stereoisomer, Cis-Trans Curcumin, as a Novel Ligand to A
A1AR
A3AR
adenosine receptors
curcumin
pain
photochemistry
vanilloid compounds
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
22 Jun 2023
22 Jun 2023
Historique:
received:
23
03
2023
revised:
05
06
2023
accepted:
16
06
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Adenosine receptors (ARs) are being explored to generate non-opioid pain therapeutics. Vanilloid compounds, curcumin, capsaicin, and vanillin possess antinociceptive properties through their interactions with the transient receptor potential channel family. However, their binding with adenosine receptors has not been well studied. The hypothesis in this study was that a vanilloid compound, cis-trans curcumin (CTCUR), binds to each of the two Gi-linked AR subtypes (A
Identifiants
pubmed: 37513829
pii: ph16070917
doi: 10.3390/ph16070917
pmc: PMC10385834
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103427
Pays : United States
Organisme : NCRR NIH HHS
ID : P20 RR016469
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115458
Pays : United States
Organisme : NIH HHS
ID : 5P20GM103427
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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