Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ) Loaded with Platinum-Based Anticancer Agents-A Novel Polymer Formulation for Anticancer Therapy.
anticancer
drug delivery
platinum(IV) complexes
quaternary ammonium glycol chitosan (GCPQ)
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
19 Jul 2023
19 Jul 2023
Historique:
received:
21
06
2023
revised:
05
07
2023
accepted:
14
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Quaternary ammonium palmitoyl glycol chitosan (GCPQ) has already shown beneficial drug delivery properties and has been studied as a carrier for anticancer agents. Consequently, we synthesised cytotoxic platinum(IV) conjugates of cisplatin, carboplatin and oxaliplatin by coupling via amide bonds to five GCPQ polymers differing in their degree of palmitoylation and quaternisation. The conjugates were characterised by
Identifiants
pubmed: 37513938
pii: ph16071027
doi: 10.3390/ph16071027
pmc: PMC10386324
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Hochschuljubiläumsfonds of the City of Vienna
ID : H-320163/2018
Références
Eur J Med Chem. 2020 May 15;194:112229
pubmed: 32222677
Med Res Rev. 2015 Nov;35(6):1268-99
pubmed: 26280923
Polymers (Basel). 2019 Nov 08;11(11):
pubmed: 31717269
Int J Biol Macromol. 2013 Aug;59:46-58
pubmed: 23608103
Dalton Trans. 2018 May 15;47(19):6645-6653
pubmed: 29632935
J Med Chem. 2007 Jul 26;50(15):3403-11
pubmed: 17602547
Nanomaterials (Basel). 2022 Jun 27;12(13):
pubmed: 35808034
Metallomics. 2017 Mar 22;9(3):309-322
pubmed: 28205649
Biomacromolecules. 2006 Dec;7(12):3452-9
pubmed: 17154474
Int J Pharm. 2009 Jun 22;375(1-2):97-106
pubmed: 19481695
Mol Pharm. 2012 Jun 4;9(6):1665-80
pubmed: 22574705
J Inorg Biochem. 2012 Dec;117:220-9
pubmed: 22877926
Int J Pharm. 2001 Aug 14;224(1-2):185-99
pubmed: 11472828
Bioorg Chem. 2019 Jul;88:102925
pubmed: 31003078
J Pers Med. 2021 Jun 18;11(6):
pubmed: 34207137
Nanomedicine (Lond). 2016 Feb;11(4):331-44
pubmed: 26786002
Inorg Chem. 2016 Feb 15;55(4):1580-6
pubmed: 26812023
Adv Mater. 2020 Dec;32(51):e2002197
pubmed: 33051905
Theranostics. 2020 Jun 25;10(17):7921-7924
pubmed: 32685029
Pharm Nanotechnol. 2019;7(1):57-71
pubmed: 30854985
Dalton Trans. 2016 Aug 16;45(33):12983-91
pubmed: 27214873
Pharmaceutics. 2022 Nov 15;14(11):
pubmed: 36432656
Int J Nanomedicine. 2018 Dec 18;14:1-15
pubmed: 30587981
Pharmaceutics. 2023 Mar 24;15(4):
pubmed: 37111536
J Inorg Biochem. 2021 Apr;217:111353
pubmed: 33477089
Chemistry. 2015 Jun 15;21(25):9185-97
pubmed: 25950156