Covalent Inhibitors for Neglected Diseases: An Exploration of Novel Therapeutic Options.
Chagas disease
Malaria
covalent target enzyme inhibitors
sleeping sickness
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
19 Jul 2023
19 Jul 2023
Historique:
received:
24
03
2023
revised:
19
06
2023
accepted:
27
06
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Neglected diseases, primarily found in tropical regions of the world, present a significant challenge for impoverished populations. Currently, there are 20 diseases considered neglected, which greatly impact the health of affected populations and result in difficult-to-control social and economic consequences. Unfortunately, for the majority of these diseases, there are few or no drugs available for patient treatment, and the few drugs that do exist often lack adequate safety and efficacy. As a result, there is a pressing need to discover and design new drugs to address these neglected diseases. This requires the identification of different targets and interactions to be studied. In recent years, there has been a growing focus on studying enzyme covalent inhibitors as a potential treatment for neglected diseases. In this review, we will explore examples of how these inhibitors have been used to target Human African Trypanosomiasis, Chagas disease, and Malaria, highlighting some of the most promising results so far. Ultimately, this review aims to inspire medicinal chemists to pursue the development of new drug candidates for these neglected diseases, and to encourage greater investment in research in this area.
Identifiants
pubmed: 37513939
pii: ph16071028
doi: 10.3390/ph16071028
pmc: PMC10385647
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1319-27
pubmed: 26057671
Bioorg Med Chem. 2016 Jun 15;24(12):2654-9
pubmed: 27137361
Bioorg Med Chem. 2018 Sep 1;26(16):4624-4634
pubmed: 30037754
ACS Med Chem Lett. 2019 Feb 20;10(4):590-595
pubmed: 30996801
J Enzyme Inhib Med Chem. 2016 Dec;31(6):1184-91
pubmed: 26572904
ChemMedChem. 2015 Sep;10(9):1484-7
pubmed: 26179752
ChemMedChem. 2013 Dec;8(12):2070-6
pubmed: 24243827
Bioorg Med Chem Lett. 2015 Aug 15;25(16):3221-5
pubmed: 26091727
Bioorg Med Chem Lett. 2018 May 15;28(9):1647-1651
pubmed: 29609908
J Med Chem. 2018 Apr 26;61(8):3350-3369
pubmed: 29590750
PLoS Negl Trop Dis. 2017 Feb 21;11(2):e0005343
pubmed: 28222138
PLoS Negl Trop Dis. 2010 Jun 08;4(6):e701
pubmed: 20544024
J Enzyme Inhib Med Chem. 2022 Dec;37(1):912-929
pubmed: 35306933
Structure. 2006 Mar;14(3):451-6
pubmed: 16531229
PLoS Pathog. 2011 Sep;7(9):e1002139
pubmed: 21909255
Mol Divers. 2022 Feb;26(1):39-50
pubmed: 33216257
Free Radic Biol Med. 2016 Jun;95:27-42
pubmed: 26923386
PLoS One. 2013 Apr 16;8(4):e60955
pubmed: 23613764
Bioorg Med Chem Lett. 2017 Nov 15;27(22):5031-5035
pubmed: 29054358
PLoS Pathog. 2019 Jun 6;15(6):e1007722
pubmed: 31170268
J Med Chem. 2019 Jun 13;62(11):5562-5578
pubmed: 31062592
ACS Med Chem Lett. 2022 Jun 30;13(7):1083-1090
pubmed: 35859868
Drug Discov Today. 2020 Jun;25(6):983-996
pubmed: 32298798
ChemMedChem. 2020 Jun 4;15(11):995-1001
pubmed: 32329206
J Biol Chem. 2013 Sep 20;288(38):27456-27468
pubmed: 23900839
Phys Chem Chem Phys. 2018 Sep 26;20(37):24317-24328
pubmed: 30211406
J Med Chem. 2019 Oct 24;62(20):9026-9044
pubmed: 31539239
ChemMedChem. 2020 Aug 19;15(16):1552-1561
pubmed: 32567172
J Chem Inf Model. 2020 Mar 23;60(3):1666-1677
pubmed: 32126170
Bioorg Med Chem Lett. 2020 Jul 15;30(14):127217
pubmed: 32527539
Bioorg Chem. 2018 Sep;79:285-292
pubmed: 29783099
Med Chem. 2017;13(2):149-158
pubmed: 27396731
Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):
pubmed: 34548400
ACS Med Chem Lett. 2020 Jan 15;11(5):806-810
pubmed: 32435388
Chemistry. 2012 May 21;18(21):6528-41
pubmed: 22488888
Future Med Chem. 2021 Jan;13(1):25-43
pubmed: 33289603
Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1705-10
pubmed: 16446443
Biochem Biophys Res Commun. 1968 Sep 6;32(5):898-902
pubmed: 5682314
J Med Chem. 2017 Aug 24;60(16):6911-6923
pubmed: 28763614
J Med Chem. 2020 Mar 26;63(6):3298-3316
pubmed: 32125159
Arch Pharm (Weinheim). 2018 Jun;351(6):e1700373
pubmed: 29672908
Elife. 2013 Jul 09;2:e00712
pubmed: 23853713
ACS Med Chem Lett. 2020 Sep 01;11(11):2131-2138
pubmed: 33209191
Antimicrob Agents Chemother. 2014;58(2):1167-78
pubmed: 24323474
Mol Biochem Parasitol. 2016 Mar-Apr;206(1-2):67-74
pubmed: 26592324
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5311-6
pubmed: 9560272
Bioorg Med Chem. 2019 Nov 15;27(22):115083
pubmed: 31561938
Nat Rev Drug Discov. 2011 Apr;10(4):307-17
pubmed: 21455239
J Med Chem. 2019 Dec 12;62(23):10617-10629
pubmed: 31714776
ACS Med Chem Lett. 2022 Aug 15;13(10):1574-1581
pubmed: 36262386
Angew Chem Int Ed Engl. 2022 Feb 7;61(7):e202115157
pubmed: 34904335
ChemMedChem. 2012 Sep;7(9):1594-600
pubmed: 22753258
Molecules. 2020 Apr 21;25(8):
pubmed: 32326257
RSC Chem Biol. 2023 May 15;4(6):422-430
pubmed: 37292058
Eur J Med Chem. 2022 Jun 5;236:114328
pubmed: 35385806
Bioorg Med Chem Lett. 2015 Oct 15;25(20):4509-12
pubmed: 26342866
J Med Chem. 2014 Sep 11;57(17):7465-71
pubmed: 25137375
Eur J Med Chem. 2016 Jan 27;108:436-443
pubmed: 26708110
J Med Chem. 2018 Nov 21;61(22):10053-10066
pubmed: 30373366
ChemMedChem. 2013 Jun;8(6):967-75
pubmed: 23658062
J Med Chem. 2022 Mar 10;65(5):4255-4269
pubmed: 35188371
ChemMedChem. 2016 Jan 5;11(1):10-4
pubmed: 26607551
J Med Chem. 2005 Dec 1;48(24):7688-707
pubmed: 16302809
Philos Trans R Soc Lond B Biol Sci. 2009 Jan 12;364(1513):71-83
pubmed: 18930878
Org Biomol Chem. 2012 Aug 14;10(30):5764-8
pubmed: 22336919
J Biol Chem. 2012 Mar 16;287(12):8792-802
pubmed: 22275351
Cell Mol Life Sci. 2001 Apr;58(4):596-624
pubmed: 11361094
J Med Chem. 2014 Aug 14;57(15):6479-94
pubmed: 25007262
Mol Microbiol. 2010 Aug;77(3):658-71
pubmed: 20545846
Bioorg Med Chem. 2021 Jul 1;41:116211
pubmed: 33991733
SLAS Discov. 2017 Jan;22(1):3-20
pubmed: 27703080
Molecules. 2019 Dec 30;25(1):
pubmed: 31905815
Nature. 2016 Feb 11;530(7589):233-6
pubmed: 26863983
Molecules. 2019 Oct 16;24(20):
pubmed: 31623252
PLoS One. 2013;8(2):e56788
pubmed: 23451087
Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3640-3644
pubmed: 30605929
Angew Chem Int Ed Engl. 2008;47(23):4331-4
pubmed: 18404765
Molecules. 2022 Jun 11;27(12):
pubmed: 35744891
Future Med Chem. 2020 Aug;12(15):1363-1368
pubmed: 32597212
J Med Chem. 2021 Aug 26;64(16):12322-12358
pubmed: 34378914
J Med Chem. 2018 Apr 26;61(8):3370-3388
pubmed: 29590751
PLoS Negl Trop Dis. 2015 Jul 14;9(7):e0003916
pubmed: 26173110
Bioorg Med Chem. 2021 Jul 1;41:116213
pubmed: 33992862
Bioorg Med Chem Lett. 2010 Dec 15;20(24):7444-9
pubmed: 21041084
Br J Pharmacol. 2007 Dec;152(8):1155-71
pubmed: 17618313
Bioorg Med Chem Lett. 2017 Jan 1;27(1):45-50
pubmed: 27890381
Mol Biochem Parasitol. 2005 Feb;139(2):185-95
pubmed: 15664653
J Biol Chem. 2009 Sep 18;284(38):25697-703
pubmed: 19620707
Biochemistry. 2012 Oct 30;51(43):8514-29
pubmed: 22957700
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3453-6
pubmed: 27372809
An Acad Bras Cienc. 2019;91 Suppl 3:e20190105
pubmed: 31166478
ACS Med Chem Lett. 2021 Oct 13;12(11):1726-1732
pubmed: 34795860
Mol Microbiol. 2005 Oct;58(1):46-60
pubmed: 16164548
J Med Chem. 2014 Dec 26;57(24):10557-63
pubmed: 25412465
PLoS Negl Trop Dis. 2015 Jun 04;9(6):e0003773
pubmed: 26042772
Expert Opin Ther Pat. 2013 Feb;23(2):165-87
pubmed: 23228154
ChemMedChem. 2014 Feb;9(2):371-82
pubmed: 24403089
PLoS Negl Trop Dis. 2018 Oct 29;12(10):e0006853
pubmed: 30372428
ACS Infect Dis. 2020 Nov 13;6(11):2815-2817
pubmed: 33054158
J Glob Antimicrob Resist. 2022 Mar;28:84-89
pubmed: 34929377
Mar Drugs. 2014 May 02;12(5):2614-22
pubmed: 24798927
Nat Microbiol. 2020 Oct;5(10):1207-1216
pubmed: 32661312