Lipid-Based Nanosystems for the Topical Application of Ferulic Acid: A Comparative Study.
antioxidant molecules
cryo-TEM
ferulic acid
monoolein aqueous dispersions
topical application
transferosomes
vesicles
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
12 Jul 2023
12 Jul 2023
Historique:
received:
31
05
2023
revised:
06
07
2023
accepted:
11
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
In this study, we examined and compared two different lipid-based nanosystems (LBNs), namely Transferosomes (TFs) and Monoolein Aqueous Dispersions (MADs), as delivery systems for the topical application of Ferulic Acid (FA), an antioxidant molecule derived from natural sources. Our results, as demonstrated through Franz-cell experiments, indicate that the LBNs produced with poloxamer 188 in their composition create a multilamellar system. This system effectively controls the release of the drug. Nonetheless, we found that the type of non-ionic surfactant can impact the drug release rate. Regarding FA diffusion from the MAD, this showed a lower diffusion rate compared with the TF. In terms of an in vivo application, patch tests revealed that all LBN formulations tested were safe when applied under occlusive conditions for 48 h. Additionally, human skin biopsies were used to determine whether FA-containing formulations could influence skin tissue morphology or provide protection against O
Identifiants
pubmed: 37514126
pii: pharmaceutics15071940
doi: 10.3390/pharmaceutics15071940
pmc: PMC10385185
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Education, Universities and Research
ID : Piano Operativo Nazionale 2014 - 2020 Azione IV.6 - Contratti di ricerca su tematiche Green 2021-PON-DM-1062-MS-RIC
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