Endothelial Glycocalyx Integrity in Treatment-Naïve People Living with HIV before and One Year after Antiretroviral Treatment Initiation.
HIV
antiretroviral treatment
atherosclerosis
biomarkers
endothelial glycocalyx
integrase inhibitor
permeable boundary region
protease inhibitor
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
05 07 2023
05 07 2023
Historique:
received:
06
05
2023
revised:
13
06
2023
accepted:
29
06
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Endothelial glycocalyx (EG) derangement has been associated with cardiovascular disease (CVD). Studies on EG integrity among people living with HIV (PLWH), are lacking. We conducted a prospective cohort study among treatment-naïve PLWH who received emtricitabine/tenofovir alafenamide, combined with either an integrase strand transfer inhibitor (INSTI, dolutegravir, raltegravir or elvitegravir/cobicistat), or a protease inhibitor (PI, darunavir/cobicistat). We assessed EG at baseline, 24 (±4) and 48 (±4) weeks, by measuring the perfused boundary region (PBR, inversely proportional to EG thickness), in sublingual microvessels. In total, 66 consecutive PLWH (60 (90.9%) males) with a median age (interquartile range, IQR) of 37 (12) years, were enrolled. In total, 40(60.6%) received INSTI-based regimens. The mean (standard deviation) PBR decreased significantly from 2.17 (0.29) μm at baseline to 2.04 (0.26) μm (
Identifiants
pubmed: 37515191
pii: v15071505
doi: 10.3390/v15071505
pmc: PMC10383742
pii:
doi:
Substances chimiques
HIV Integrase Inhibitors
0
Cobicistat
LW2E03M5PG
Anti-HIV Agents
0
Anti-Retroviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
J Cereb Blood Flow Metab. 2023 May 26;:271678X231179413
pubmed: 37231664
Matrix Biol Plus. 2021 Nov 27;12:100094
pubmed: 34917925
Front Cardiovasc Med. 2022 May 13;9:897087
pubmed: 35647072
J Hum Hypertens. 2022 Dec;36(12):1113-1120
pubmed: 34819613
Open Forum Infect Dis. 2020 Sep 12;7(10):ofaa425
pubmed: 33094120
Sci Rep. 2021 Jun 9;11(1):12157
pubmed: 34108510
Curr Heart Fail Rep. 2017 Apr;14(2):117-126
pubmed: 28233259
J Clin Hypertens (Greenwich). 2018 Nov;20(11):1615-1623
pubmed: 30315671
Anaesthesia. 2014 Jul;69(7):777-84
pubmed: 24773303
Basic Res Cardiol. 2021 Feb 6;116(1):9
pubmed: 33547969
AIDS Res Hum Retroviruses. 2023 Apr 25;:
pubmed: 36924277
Eur J Cardiovasc Prev Rehabil. 2011 Dec;18(6):775-89
pubmed: 21450600
J Clin Monit Comput. 2022 Apr;36(2):371-377
pubmed: 33534119
Front Cardiovasc Med. 2018 Dec 19;5:185
pubmed: 30619892
J Cereb Blood Flow Metab. 2014 Jul;34(7):1107-10
pubmed: 24756075
Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):175-191
pubmed: 36453273
Pflugers Arch. 2007 Jun;454(3):345-59
pubmed: 17256154
Microcirculation. 2018 May;25(4):e12454
pubmed: 29608790
Hellenic J Cardiol. 2023 May-Jun;71:42-54
pubmed: 36646212
Lancet. 2007 Oct 20;370(9596):1453-7
pubmed: 18064739
Front Immunol. 2021 May 17;12:663412
pubmed: 34079548
AIDS Res Hum Retroviruses. 2017 Jul;33(7):703-710
pubmed: 28260391
J Clin Hypertens (Greenwich). 2018 Apr;20(4):672-679
pubmed: 29498204
Physiol Rep. 2020 Jan;8(2):e14351
pubmed: 31960625
Am J Cardiol. 2016 Jan 15;117(2):214-20
pubmed: 26639041
Transl Res. 2022 Sep;247:158-167
pubmed: 35421613
Curr Opin HIV AIDS. 2016 Mar;11(2):129-30
pubmed: 26845672
Atherosclerosis. 2018 Nov;278:166-173
pubmed: 30278359
Circulation. 2018 Sep 11;138(11):1100-1112
pubmed: 29967196
HIV Med. 2021 Sep;22(8):732-741
pubmed: 34028959
J Intern Med. 2006 Apr;259(4):393-400
pubmed: 16594907
Circulation. 2018 Sep 11;138(11):1113-1115
pubmed: 30354392
PLoS One. 2022 Oct 19;17(10):e0276232
pubmed: 36260622
Lancet. 2008 Apr 26;371(9622):1417-26
pubmed: 18387667
Cardiovasc Res. 2021 Jan 1;117(1):29-42
pubmed: 32282914
BMC Med. 2019 Jul 3;17(1):128
pubmed: 31266500
J Appl Physiol (1985). 2008 Mar;104(3):845-52
pubmed: 18162484
Life (Basel). 2021 Aug 05;11(8):
pubmed: 34440534
Trends Mol Med. 2016 Jun;22(6):453-457
pubmed: 27161599
J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12
pubmed: 17456578
Scand J Trauma Resusc Emerg Med. 2018 Feb 14;26(1):16
pubmed: 29444696
BMC Public Health. 2020 May 20;20(1):734
pubmed: 32434482
Int J Cardiol. 2017 Apr 15;233:105-112
pubmed: 28096045
Biomedicines. 2021 Jun 20;9(6):
pubmed: 34203043
PLoS One. 2019 Mar 27;14(3):e0213097
pubmed: 30917159
AIDS. 2016 Jun 19;30(10):1495-509
pubmed: 27058351