Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review.
T-cell transfer
adenovirus
cellular therapy
central nervous system
cytomegalovirus
encephalitis
immune therapy
multiple sclerosis
progressive multifocal leukoencephalopathy
viral infections
virus-specific T-cells
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
06 07 2023
06 07 2023
Historique:
received:
08
06
2023
revised:
29
06
2023
accepted:
03
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Opportunistic viral infections of the central nervous system represent a significant cause of morbidity and mortality among an increasing number of immunocompromised patients. Since antiviral treatments are usually poorly effective, the prognosis generally relies on the ability to achieve timely immune reconstitution. Hence, strategies aimed at reinvigorating antiviral immune activity have recently emerged. Among these, virus-specific T-cells are increasingly perceived as a principled and valuable tool to treat opportunistic viral infections. Here we briefly discuss how to develop and select virus-specific T-cells, then review their main indications in central nervous system infections, including progressive multifocal leukoencephalopathy, CMV infection, and adenovirus infection. We also discuss their potential interest in the treatment of progressive multiple sclerosis, or EBV-associated central nervous system inflammatory disease. We finish with the key future milestones of this promising treatment strategy.
Identifiants
pubmed: 37515196
pii: v15071510
doi: 10.3390/v15071510
pmc: PMC10383098
pii:
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Br J Haematol. 2006 Jul;134(1):64-76
pubmed: 16803570
Blood. 2013 Jun 27;121(26):5113-23
pubmed: 23610374
Br J Haematol. 2005 Aug;130(4):595-603
pubmed: 16098075
J Immunol. 2002 Jan 1;168(1):499-504
pubmed: 11751998
Annu Rev Microbiol. 2000;54:19-48
pubmed: 11018123
Blood Adv. 2017 Nov 02;1(24):2193-2205
pubmed: 29296867
Lancet. 2003 Oct 25;362(9393):1375-7
pubmed: 14585640
Mult Scler. 2014 Oct;20(11):1541-4
pubmed: 24493474
J Immunol Methods. 1990 Apr 17;128(2):189-201
pubmed: 1691237
J Heart Lung Transplant. 2022 Jul;41(7):991-996
pubmed: 35595631
Mol Ther. 2015 Jan;23(1):179-83
pubmed: 25266309
Bone Marrow Transplant. 1994 Oct;14(4):663-4
pubmed: 7858548
Blood. 2017 Apr 6;129(14):2033-2037
pubmed: 28153824
Ann Neurol. 2013 Sep;74(3):412-22
pubmed: 23913580
N Engl J Med. 2019 Apr 25;380(17):1597-1605
pubmed: 30969503
Ther Adv Hematol. 2020 Jun 24;11:2040620720937150
pubmed: 32637057
Nat Rev Neurol. 2021 Jan;17(1):37-51
pubmed: 33219338
FEBS Lett. 2019 Dec;593(24):3571-3582
pubmed: 31411731
Br J Haematol. 2005 Jan;128(2):135-44
pubmed: 15638847
CNS Drugs. 2002;16(5):303-15
pubmed: 11994020
J Hematol Oncol. 2017 May 8;10(1):102
pubmed: 28482908
Ann Neurol. 2021 Apr;89(4):769-779
pubmed: 33459417
Blood. 2010 Dec 2;116(23):5045-9
pubmed: 20826724
AIDS. 1996 Nov;10(13):1515-20
pubmed: 8931786
Blood. 2015 Mar 19;125(12):1986-94
pubmed: 25617426
Front Immunol. 2017 Oct 11;8:1272
pubmed: 29075259
Front Oncol. 2019 Aug 06;9:713
pubmed: 31448229
Biol Blood Marrow Transplant. 2019 Apr;25(4):810-818
pubmed: 30578939
Eur J Immunol. 1999 Dec;29(12):4053-9
pubmed: 10602016
J Exp Med. 2007 Nov 26;204(12):2899-912
pubmed: 17984305
Blood Adv. 2021 Sep 14;5(17):3309-3321
pubmed: 34473237
Science. 2022 Jan 21;375(6578):296-301
pubmed: 35025605
J Immunol. 2006 Oct 1;177(7):4897-906
pubmed: 16982932
Transpl Int. 2016 May;29(5):515-26
pubmed: 26284570
J Antimicrob Chemother. 2010 Dec;65(12):2628-40
pubmed: 20961907
Blood. 2009 Nov 26;114(23):4784-91
pubmed: 19759356
Nat Rev Clin Oncol. 2012 Sep;9(9):510-9
pubmed: 22801669
J Clin Oncol. 2017 Nov 1;35(31):3547-3557
pubmed: 28783452
Am J Hematol. 2022 Jun 1;97(6):762-769
pubmed: 35293011
Biol Blood Marrow Transplant. 2015 Sep;21(9):1663-78
pubmed: 26028505
Blood. 2010 Nov 18;116(20):4360-7
pubmed: 20625005
Blood. 2020 Apr 23;135(17):1447-1451
pubmed: 32076716
Oncoimmunology. 2017 Jan 4;6(2):e1273311
pubmed: 28344888
Biol Blood Marrow Transplant. 2007 Jun;13(6):707-14
pubmed: 17531781
Hematology. 2020 Dec;25(1):43-47
pubmed: 31906810
Front Immunol. 2013 Oct 14;4:330
pubmed: 24133497
Expert Rev Anti Infect Ther. 2013 Oct;11(10):1017-28
pubmed: 24073835
Curr Top Microbiol Immunol. 2018;417:211-248
pubmed: 29256135
Blood. 2001 Feb 15;97(4):994-1000
pubmed: 11159528
Lancet Neurol. 2021 Aug;20(8):639-652
pubmed: 34302788
J Vis Exp. 2011 May 27;(51):
pubmed: 21654628
Ann Neurol. 2023 Feb;93(2):257-270
pubmed: 36151879
N Engl J Med. 2018 Oct 11;379(15):1443-1451
pubmed: 30304652
J Allergy Clin Immunol. 2016 Sep;138(3):920-924.e3
pubmed: 27246524
Clin Microbiol Rev. 2014 Jul;27(3):441-62
pubmed: 24982316
Rev Med Virol. 2018 May;28(3):e1980
pubmed: 29663594
N Engl J Med. 1994 Apr 28;330(17):1185-91
pubmed: 8093146
Neurol Neuroimmunol Neuroinflamm. 2018 Jun 07;5(4):e466
pubmed: 29892607
Blood. 2002 Jun 1;99(11):3916-22
pubmed: 12010789
Brain. 2023 Jan 5;146(1):349-358
pubmed: 35779271
J Neuropathol Exp Neurol. 2010 Jul;69(7):677-93
pubmed: 20535037
J Clin Virol. 2013 Aug;57(4):300-4
pubmed: 23619053
Emerg Infect Dis. 2022 Jan;28(1):
pubmed: 34856110
Clin Exp Immunol. 2003 Apr;132(1):96-104
pubmed: 12653843
J Neuropathol Exp Neurol. 2013 Jan;72(1):29-41
pubmed: 23242282
Bone Marrow Transplant. 2022 Feb;57(2):271-275
pubmed: 34671119
Expert Opin Biol Ther. 2021 May;21(5):649-659
pubmed: 33249924
Exp Hematol. 2004 Mar;32(3):282-9
pubmed: 15003314
Clin Infect Dis. 2011 Jan 1;52(1):49-57
pubmed: 21148519
Transplant Cell Ther. 2022 Feb;28(2):116.e1-116.e7
pubmed: 34785398
Blood. 2015 Dec 24;126(26):2781-9
pubmed: 26508783
J Cancer Res Clin Oncol. 2022 Jan;148(1):31-46
pubmed: 34705104
Cytotherapy. 2018 Jun;20(6):830-838
pubmed: 29753677
J Immunother. 2008 Jun;31(5):500-5
pubmed: 18463534
J Clin Oncol. 2021 Aug 20;39(24):2710-2719
pubmed: 33929874
Blood. 2009 Nov 5;114(19):4283-92
pubmed: 19700662
Sci Transl Med. 2014 Jun 25;6(242):242ra83
pubmed: 24964991
Front Immunol. 2022 Feb 22;13:805657
pubmed: 35273596
Pediatr Transplant. 2019 Dec;23(8):e13584
pubmed: 31556188
Haematologica. 2011 Jan;96(1):142-9
pubmed: 20851868
J Adv Pract Oncol. 2019 Mar;10(2):120-131
pubmed: 31538024
J Neurol Sci. 2018 May 15;388:28-36
pubmed: 29627026
J Virol. 2009 Jun;83(12):6192-8
pubmed: 19357166
Bone Marrow Transplant. 2011 Jul;46(7):987-92
pubmed: 20921942
Curr Opin Organ Transplant. 2018 Aug;23(4):395-399
pubmed: 29846196
J Gen Virol. 2006 Oct;87(Pt 10):2951-2960
pubmed: 16963754
Blood. 2010 Nov 25;116(22):4700-2
pubmed: 20709906
Am J Transplant. 2009 Dec;9 Suppl 4:S78-86
pubmed: 20070700
Am J Transplant. 2013 Dec;13(12):3244-52
pubmed: 24266973
Front Immunol. 2022 May 03;13:889148
pubmed: 35592313
Brain. 2010 Dec;133(Pt 12):e157
pubmed: 20739348
Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1921-5
pubmed: 7892200
Immunol Rev. 2012 Jul;248(1):216-27
pubmed: 22725964
Clin Microbiol Rev. 2020 Oct 28;34(1):
pubmed: 33115722
Nat Rev Immunol. 2017 Mar;17(3):179-194
pubmed: 28138136
Blood. 2006 Feb 1;107(3):1230-2
pubmed: 16239436
J Immunother. 2008 Sep;31(7):665-74
pubmed: 18600178
Annu Rev Immunol. 2007;25:587-617
pubmed: 17378764
Clin Infect Dis. 1999 Dec;29(6):1494-501
pubmed: 10585802
J Virol. 2005 Sep;79(17):11170-8
pubmed: 16103168
Biol Blood Marrow Transplant. 2011 Jun;17(6):800-9
pubmed: 21215812
Clin Transl Immunology. 2015 Jan 16;4(1):e31
pubmed: 25671129
Trends Mol Med. 2021 Apr;27(4):410-411
pubmed: 33608230
JCI Insight. 2018 Nov 15;3(22):
pubmed: 30429369
Viruses. 2022 Oct 27;14(11):
pubmed: 36366468
J Immunother. 2014 Apr;37(3):170-9
pubmed: 24598452
J Virol. 2005 Oct;79(20):13094-104
pubmed: 16189011
J Immunother. 2018 Apr;41(3):158-163
pubmed: 29239916
Nat Rev Microbiol. 2023 Jan;21(1):51-64
pubmed: 35931816
Curr Neurol Neurosci Rep. 2021 May 26;21(7):37
pubmed: 34037866
J Pediatr. 2019 Feb;205:130-137
pubmed: 30413311
Eur J Neurol. 2021 Nov;28(11):3814-3819
pubmed: 34251719
J Thorac Dis. 2016 May;8(5):803-12
pubmed: 27162653
Blood. 2002 Sep 1;100(5):1619-27
pubmed: 12176880
J Neurol. 2022 May;269(5):2403-2413
pubmed: 34994851
J Infect Dis. 2014 Feb 15;209(4):557-61
pubmed: 23983215
AIDS. 2013 Feb 20;27(4):597-605
pubmed: 23079812
Mult Scler. 2020 Dec;26(14):1816-1821
pubmed: 33174475
Clin Transl Immunology. 2023 Mar 21;12(3):e1444
pubmed: 36960148
Neurol Neuroimmunol Neuroinflamm. 2021 Jul 20;8(5):
pubmed: 34285093
Cytotherapy. 2010 Oct;12(6):743-9
pubmed: 20429793
Immunology. 2021 Jan;162(1):30-43
pubmed: 32935333
N Engl J Med. 1995 Oct 19;333(16):1038-44
pubmed: 7675046
Curr Top Microbiol Immunol. 2015;391:427-54
pubmed: 26428384
Ann Neurol. 2022 Apr;91(4):496-505
pubmed: 35072281
Nat Rev Immunol. 2019 Nov;19(11):665-674
pubmed: 31570879
Curr Opin Virol. 2013 Jun;3(3):227-32
pubmed: 23683686
Curr Opin Crit Care. 2017 Apr;23(2):128-133
pubmed: 28169858
J Clin Invest. 2023 May 15;133(10):
pubmed: 36951958
Bone Marrow Transplant. 2010 Jun;45(6):979-84
pubmed: 20190836
Viruses. 2019 Dec 23;12(1):
pubmed: 31878068
JAMA. 2021 Feb 23;325(8):765-779
pubmed: 33620411
Blood. 2020 May 7;135(19):1619-1629
pubmed: 32202631
Science. 1992 Jul 10;257(5067):238-41
pubmed: 1352912
Blood Adv. 2023 Apr 25;7(8):1394-1403
pubmed: 36595478
Case Rep Infect Dis. 2023 May 22;2023:5528198
pubmed: 37261248
Front Neurol. 2021 Mar 15;12:652811
pubmed: 33790852
Neurol Neuroimmunol Neuroinflamm. 2021 May 17;8(4):
pubmed: 34001660
Immunotherapy. 2014;6(6):659-61
pubmed: 25186599
Semin Respir Crit Care Med. 2016 Aug;37(4):586-602
pubmed: 27486739
Lancet. 1995 Jan 7;345(8941):9-13
pubmed: 7799740
N Engl J Med. 1989 Oct 19;321(16):1080-5
pubmed: 2552313
J Transl Med. 2020 Apr 21;18(1):177
pubmed: 32316991
Clin Infect Dis. 2019 Feb 1;68(4):632-640
pubmed: 29982441
Clin Infect Dis. 2001 Mar 15;32(6):871-6
pubmed: 11247710
PLoS One. 2018 Feb 2;13(2):e0192109
pubmed: 29394264
J Clin Med. 2022 Aug 18;11(16):
pubmed: 36013066
Expert Opin Biol Ther. 2010 Mar;10(3):337-51
pubmed: 20132056
Drugs. 2013 Feb;73(2):131-58
pubmed: 23377760