Atypical Hepatitis B Virus Serology Profile-Hepatitis B Surface Antigen-Positive/Hepatitis B Core Antibody-Negative-In Hepatitis B Virus/HIV Coinfected Individuals in Botswana.
Africa
Botswana
HBV
HIV
hepatitis B core antibodies (anti-HBc)
hepatitis B surface antigen (HBsAg)
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
13 07 2023
13 07 2023
Historique:
received:
19
06
2023
revised:
10
07
2023
accepted:
11
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
(1) Background: Hepatitis B core antibodies (anti-HBc) are a marker of hepatitis B virus (HBV) exposure; hence, a normal HBV serology profile is characterized by HBV surface antigen (HBsAg) and anti-HBc positivity. However, atypical HBV serologies occur, and we aimed to determine the prevalence of an atypical profile (HBsAg+/anti-HBc-) in a cohort of people with HIV-1 (PWH) in Botswana. (2) Methods: Plasma samples from an HIV-1 cohort in Botswana (2013-2018) were used. The samples were screened for HBsAg and anti-HBc. Next-generation sequencing was performed using the GridION platform. The Wilcoxon rank-sum test and Chi-squared tests were used for the comparison of continuous and categorical variables, respectively. (3) Results: HBsAg+/anti-HBc- prevalence was 13.7% (95% CI 10.1-18.4) (36/263). HBsAg+/anti-HBc- participants were significantly younger (
Identifiants
pubmed: 37515230
pii: v15071544
doi: 10.3390/v15071544
pmc: PMC10383918
pii:
doi:
Substances chimiques
Hepatitis B Surface Antigens
0
DNA, Viral
0
Hepatitis B Antibodies
0
Hepatitis B Core Antigens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 218770/Z/19/Z
Pays : United Kingdom
Organisme : NIH HHS
ID : U41HG006941
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-033558
Pays : United States
Organisme : NIH HHS
ID : D43 TW009610
Pays : United States
Organisme : NIH HHS
ID : K43 012350
Pays : United States
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