Postnatal growth restriction impairs rat lung structure and function.
growth restriction
lung development
lung disease
preterm
Journal
Anatomical record (Hoboken, N.J. : 2007)
ISSN: 1932-8494
Titre abrégé: Anat Rec (Hoboken)
Pays: United States
ID NLM: 101292775
Informations de publication
Date de publication:
28 Jul 2023
28 Jul 2023
Historique:
revised:
08
07
2023
received:
01
03
2023
accepted:
13
07
2023
pubmed:
29
7
2023
medline:
29
7
2023
entrez:
29
7
2023
Statut:
aheadofprint
Résumé
The negative impact of nutritional deficits in the development of bronchopulmonary dysplasia is well recognized, yet mechanisms by which nutrition alters lung outcomes and nutritional strategies that optimize development and protect the lung remain elusive. Here, we use a rat model to assess the isolated effects of postnatal nutrition on lung structural development without concomitant lung injury. We hypothesize that postnatal growth restriction (PGR) impairs lung structure and function, critical mediators of lung development, and fatty acid profiles at postnatal day 21 in the rat. Rat pups were cross-fostered at birth to rat dams with litter sizes of 8 (control) or 16 (PGR). Lung structure and function, as well as serum and lung tissue fatty acids, and lung molecular mediators of development, were measured. Male and female PGR rat pups had thicker airspace walls, decreased lung compliance, and increased tissue damping. Male rats also had increased lung elastance, increased lung elastin protein abundance, and lysol oxidase expression, and increased elastic fiber deposition. Female rat lungs had increased conducting airway resistance and reduced levels of docosahexaenoic acid in lung tissue. We conclude that PGR impairs lung structure and function in both male and female rats, with sex-divergent changes in lung molecular mediators of development.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : HL108828
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK084036
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL108828
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK084036
Pays : United States
Informations de copyright
© 2023 American Association for Anatomy.
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