The interaction of bile acids and gut inflammation influences the pathogenesis of inflammatory bowel disease.
Crohn’s disease
Enterohepatic circulation
FXR
GPBAR1
Gut barrier
Gut microbiota
Nuclear receptors
Ulcerative colitis
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
14
01
2023
accepted:
08
06
2023
medline:
10
11
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
ppublish
Résumé
Bile acids (BA) are amphipathic molecules originating from cholesterol in the liver and from microbiota-driven biotransformation in the colon. In the gut, BA play a key role in fat digestion and absorption and act as potent signaling molecules on the nuclear farnesoid X receptor (FXR) and membrane-associated G protein-coupled BA receptor-1 (GPBAR-1). BA are, therefore, involved in the maintenance of gut barrier integrity, gene expression, metabolic homeostasis, and microbiota profile and function. Disturbed BA homeostasis can activate pro-inflammatory pathways in the gut, while inflammatory bowel diseases (IBD) can induce gut dysbiosis and qualitative and/or quantitative changes of the BA pool. These factors contribute to impaired repair capacity of the mucosal barrier, due to chronic inflammation. A better understanding of BA-dependent mechanisms paves the way to innovative therapeutic tools by administering hydrophilic BA and FXR agonists and manipulating gut microbiota with probiotics and prebiotics. We discuss the translational value of pathophysiological and therapeutic evidence linking BA homeostasis to gut inflammation in IBD.
Identifiants
pubmed: 37515676
doi: 10.1007/s11739-023-03343-3
pii: 10.1007/s11739-023-03343-3
pmc: PMC10635993
doi:
Substances chimiques
Bile Acids and Salts
0
Types de publication
Journal Article
Review
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2181-2197Subventions
Organisme : Horizon 2020
ID : 722619
Organisme : Horizon 2020
ID : 734719
Organisme : Regione Puglia
ID : H99C20000340002
Organisme : Universita degli Studi di Bari Aldo Moro
ID : EUROSEEDS Uniba - S56
Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2023. The Author(s).
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