Antibubbles Enable Tunable Payload Release with Low-Intensity Ultrasound.
antibubbles
low-intensity ultrasound
payload
smart materials
triggered release
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
25
07
2023
received:
03
06
2023
medline:
29
11
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
ppublish
Résumé
The benefits of ultrasound are its ease-of-use and its ability to precisely deliver energy in opaque and complex media. However, most materials responsive to ultrasound show a weak response, requiring the use of high powers, which are associated with undesirable streaming, cavitation, or temperature rise. These effects hinder response control and may even cause damage to the medium where the ultrasound is applied. Moreover, materials that are currently in use rely on all-or-nothing effects, limiting the ability to fine-tune the response of the material on the fly. For these reasons, there is a need for materials that can respond to low intensity ultrasound with programmable responses. Here it is demonstrated that antibubbles are a low-intensity-ultrasound-responsive material system that can controllably release a payload using acoustic pressures in the kilopascal range. Varying their size and composition tunes the release pressure, and the response can be switched between a single release and stepwise release across multiple ultrasound pulses. Observations using confocal and high-speed microscopy reveal different ways that can lead to release. These findings lay the groundwork to design antibubbles that controllably respond to low-intensity ultrasound, opening a wide range of applications ranging from ultrasound-responsive material systems to carriers for targeted delivery.
Identifiants
pubmed: 37515825
doi: 10.1002/adma.202305296
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2305296Subventions
Organisme : European Research Council
ID : 788296
Pays : International
Informations de copyright
© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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