FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6C

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
27 Jul 2023
Historique:
received: 30 03 2023
revised: 21 06 2023
accepted: 24 06 2023
pubmed: 30 7 2023
medline: 30 7 2023
entrez: 29 7 2023
Statut: aheadofprint

Résumé

Cells of the monocyte/macrophage lineage are an integral component of the body's innate ability to restore tissue function after injury. In parallel to mounting an inflammatory response, clearance of monocytes/macrophages from the wound site is critical to re-establish tissue functionality and integrity during the course of healing. The role of regulated cell death in macrophage clearance from damaged tissue and its implications for the outcome of the healing response is little understood. In this study, we explored the role of macrophage-specific FADD-mediated cell death on Ripk3

Identifiants

DOI: 10.1016/j.jid.2023.06.203 PMID: 37516311
pubmed: 37516311
pii: S0022-202X(23)02424-7
doi: 10.1016/j.jid.2023.06.203
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Auteurs

Louise Injarabian (L)

Department of Dermatology, University of Cologne, Cologne, Germany.

Sebastian Willenborg (S)

Department of Dermatology, University of Cologne, Cologne, Germany.

Daniela Welcker (D)

Department of Dermatology, University of Cologne, Cologne, Germany.

David E Sanin (DE)

Bloomberg-Kimmel Institute for Cancer Immunotherapy, Quantitative Sciences Division and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Manolis Pasparakis (M)

Institute for Genetics, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Hamid Kashkar (H)

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Institute for Molecular Immunology, University of Cologne, Cologne, Germany.

Sabine A Eming (SA)

Department of Dermatology, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Developmental Biology Unit, Institute of Zoology, University of Cologne, Cologne, Germany. Electronic address: sabine.eming@uni-koeln.de.

Classifications MeSH