Coordination-driven FBXW7 DNAzyme-Fe nanoassembly enables a binary switch of breast cancer cell cycle checkpoint responses for enhanced ferroptosis-radiotherapy.
Humans
Female
F-Box-WD Repeat-Containing Protein 7
/ genetics
DNA, Catalytic
/ metabolism
Cell Cycle Proteins
/ metabolism
Breast Neoplasms
/ genetics
F-Box Proteins
/ genetics
Tumor Suppressor Protein p53
/ genetics
Ferroptosis
Dopamine
Hyaluronic Acid
Reactive Oxygen Species
/ metabolism
Cell Line, Tumor
Ubiquitin-Protein Ligases
/ genetics
Cell Cycle Checkpoints
Breast cancer therapy
Coordination-driven self-assembly
DNAzyme-Fe nanocomplex
Ferroptosis
Gene delivery
Radiosensitization
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
received:
02
03
2023
revised:
22
06
2023
accepted:
24
07
2023
medline:
18
9
2023
pubmed:
30
7
2023
entrez:
29
7
2023
Statut:
ppublish
Résumé
Radiotherapy is a mainstream modality for breast cancer treatment that employs ionizing radiation (IR) to damage tumor cell DNA and elevate ROS stress, which demonstrates multiple clinically-favorable advantages including localized treatment and low invasiveness. However, breast cancer cells may activate the p53-mediated cell cycle regulation in response to radiotherapy to repair IR-induced cellular damage and facilitate post-treatment survival. F-Box and WD Repeat Domain Containing 7 (FBXW7) is a promoter of p53 degradation and critical nexus of cell proliferation and survival events. Herein, we engineered a cooperative radio-ferroptosis-stimulatory nanomedicine through coordination-driven self-assembly between ferroptosis-inducing Fe
Identifiants
pubmed: 37516418
pii: S1742-7061(23)00432-4
doi: 10.1016/j.actbio.2023.07.042
pii:
doi:
Substances chimiques
F-Box-WD Repeat-Containing Protein 7
0
DNA, Catalytic
0
Cell Cycle Proteins
0
F-Box Proteins
0
Tumor Suppressor Protein p53
0
Dopamine
VTD58H1Z2X
Hyaluronic Acid
9004-61-9
Reactive Oxygen Species
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
FBXW7 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
434-450Informations de copyright
Copyright © 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.