Polysomnographic Phenotypes of Obstructive Sleep Apnea in a Real-Life Cohort: A Pathophysiological Approach.

Female Humans Middle Aged Male Cross-Sectional Studies Sleep Apnea, Obstructive / epidemiology Sleep / physiology Sleep Apnea Syndromes Phenotype
Apnea–hypopnea index Cluster analysis Obstructive sleep apnea Polysomnographic phenotypes

Journal

Archivos de bronconeumologia
ISSN: 1579-2129
Titre abrégé: Arch Bronconeumol
Pays: Spain
ID NLM: 0354720

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 05 04 2023
revised: 10 07 2023
accepted: 11 07 2023
medline: 23 10 2023
pubmed: 30 7 2023
entrez: 29 7 2023
Statut: ppublish

Résumé

Obstructive sleep apnea (OSA) is heterogeneous and complex, but its severity is still based on the apnea-hypoapnea index (AHI). The present study explores using cluster analysis (CA), the additional information provided from routine polysomnography (PSG) to optimize OSA categorization. Cross-sectional study of OSA subjects diagnosed by PSG in a tertiary hospital sleep unit during 2016-2020. PSG, demographical, clinical variables, and comorbidities were recorded. Phenotypes were constructed from PSG variables using CA. Results are shown as median (interquartile range). 981 subjects were studied: 41% females, age 56 years (45-66), overall AHI 23events/h (13-42) and body mass index (BMI) 30kg/m The CA identifies three specific PSG phenotypes that do not completely agree with classical OSA severity classification. This emphasized that using a simplistic AHI approach, the OSA severity is assessed by an incorrect or incomplete analysis of the heterogeneity of the disorder.

Identifiants

DOI: 10.1016/j.arbres.2023.07.007 PMID: 37516558
pubmed: 37516558
pii: S0300-2896(23)00222-3
doi: 10.1016/j.arbres.2023.07.007
pii:
doi:

Types de publication

Journal Article

Langues

eng spa

Sous-ensembles de citation

IM

Pagination

638-644

Informations de copyright

Copyright © 2023 SEPAR. Published by Elsevier España, S.L.U. All rights reserved.

Auteurs

Mercè Gasa (M)

Sleep Unit, Respiratory Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; Department of Medicine, Campus Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain. Electronic address: mgasa@bellvitgehospital.cat.

Neus Salord (N)

Sleep Unit, Respiratory Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.

Eva Fontanilles (E)

Sleep Unit, Respiratory Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.

Sandra Pérez Ramos (S)

Sleep Unit, Respiratory Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.

Eliseo Prado (E)

Sleep Unit, Respiratory Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.

Natalia Pallarés (N)

Biostatistics Unit, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.

Salud Santos Pérez (S)

Sleep Unit, Respiratory Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; Department of Medicine, Campus Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.

Carmen Monasterio (C)

Sleep Unit, Respiratory Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain. Electronic address: cmonasterio@bellvitgehospital.cat.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Polysomnographic Phenotypes of Obstructive...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Polysomnographic Phenotypes of Obstructive...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Polysomnographic Phenotypes of Obstructive...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › Polysomnographic Phenotypes of Obstructive...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Polysomnographic Phenotypes of Obstructive...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Polysomnographic Phenotypes of Obstructive...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Polysomnographic Phenotypes of Obstructive...